Influenza A viruses alter the stability and antiviral contribution of host E3-ubiquitin ligase Mdm2 during the time-course of infection

The interplay between influenza A viruses (IAV) and the p53 pathway has been reported in several studies, highlighting the antiviral contribution of p53. Here, we investigated the impact of IAV on the E3-ubiquitin ligase Mdm2, a major regulator of p53, and observed that IAV targets Mdm2, notably via...

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Detalles Bibliográficos
Autores principales: Pizzorno, Andrés, Dubois, Julia, Machado, Daniela, Cartet, Gaëlle, Traversier, Aurelien, Julien, Thomas, Lina, Bruno, Bourdon, Jean-Christophe, Rosa-Calatrava, Manuel, Terrier, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829072/
https://www.ncbi.nlm.nih.gov/pubmed/29487367
http://dx.doi.org/10.1038/s41598-018-22139-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829072/
https://www.ncbi.nlm.nih.gov/pubmed/29487367
http://dx.doi.org/10.1038/s41598-018-22139-6

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