Cargando…

Evaluation of Polygenic Determinants of Non-Alcoholic Fatty Liver Disease (NAFLD) By a Candidate Genes Resequencing Strategy

NAFLD is a polygenic condition but the individual and cumulative contribution of identified genes remains to be established. To get additional insight into the genetic architecture of NAFLD, GWAS-identified GCKR, PPP1R3B, NCAN, LYPLAL1 and TM6SF2 genes were resequenced by next generation sequencing...

Descripción completa

Detalles Bibliográficos
Autores principales:	Di Costanzo, Alessia, Belardinilli, Francesca, Bailetti, Diego, Sponziello, Marialuisa, D’Erasmo, Laura, Polimeni, Licia, Baratta, Francesco, Pastori, Daniele, Ceci, Fabrizio, Montali, Anna, Girelli, Gabriella, De Masi, Bruna, Angeloni, Antonio, Giannini, Giuseppe, Del Ben, Maria, Angelico, Francesco, Arca, Marcello
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829219/ https://www.ncbi.nlm.nih.gov/pubmed/29487372 http://dx.doi.org/10.1038/s41598-018-21939-0

Ejemplares similares

HDL-Mediated Cholesterol Efflux and Plasma Loading Capacities Are Altered in Subjects with Metabolically- but Not Genetically Driven Non-Alcoholic Fatty Liver Disease (NAFLD)
por: Di Costanzo, Alessia, et al.
Publicado: (2020)

Metabolic Syndrome but Not Fatty Liver-Associated Genetic Variants Correlates with Glomerular Renal Function Decline in Patients with Non-Alcoholic Fatty Liver Disease
por: Baratta, Francesco, et al.
Publicado: (2022)

Does Lysosomial Acid Lipase Reduction Play a Role in Adult Non-Alcoholic Fatty Liver Disease?
por: Baratta, Francesco, et al.
Publicado: (2015)

PNPLA3 variant and portal/periportal histological pattern in patients with biopsy-proven non-alcoholic fatty liver disease: a possible role for oxidative stress
por: Carpino, Guido, et al.
Publicado: (2017)

Is the Mediterranean Diet the Best Approach to NAFLD Treatment Today?
por: Angelico, Francesco, et al.
Publicado: (2021)

Open Issues in the Transition from NAFLD to MAFLD: The Experience of the Plinio Study
por: Baratta, Francesco, et al.
Publicado: (2021)

Clinical Implications of Monogenic Versus Polygenic Hypercholesterolemia: Long‐Term Response to Treatment, Coronary Atherosclerosis Burden, and Cardiovascular Events
por: D’Erasmo, Laura, et al.
Publicado: (2021)

Genetic and metabolic predictors of hepatic fat content in a cohort of Italian children with obesity
por: Di Costanzo, Alessia, et al.
Publicado: (2019)

Reduced Lysosomal Acid Lipase Activity in Adult Patients With Non-alcoholic Fatty Liver Disease
por: Baratta, Francesco, et al.
Publicado: (2015)

Statin liver safety in non‐alcoholic fatty liver disease: A systematic review and metanalysis
por: Pastori, Daniele, et al.
Publicado: (2021)

Nonalcoholic Fatty Liver Disease (NAFLD), But not Its Susceptibility Gene Variants, Influences the Decrease of Kidney Function in Overweight/Obese Children
por: Di Costanzo, Alessia, et al.
Publicado: (2019)

Overexpression of the Vitronectin V10 Subunit in Patients with Nonalcoholic Steatohepatitis: Implications for Noninvasive Diagnosis of NASH
por: Del Ben, Maria, et al.
Publicado: (2018)

Similar Reduction of Cholesterol-Adjusted Vitamin E Serum Levels in Simple Steatosis and Non-Alcoholic Steatohepatitis
por: Pastori, Daniele, et al.
Publicado: (2015)

Moderate Weight Loss Decreases Oxidative Stress and Increases Antioxidant Status in Patients with Metabolic Syndrome
por: Del Ben, Maria, et al.
Publicado: (2012)

NOX2-generated oxidative stress is associated with severity of ultrasound liver steatosis in patients with non-alcoholic fatty liver disease
por: Del Ben, Maria, et al.
Publicado: (2014)

Non-alcoholic fatty liver disease (NAFLD), metabolic syndrome and cardiovascular events in atrial fibrillation. A prospective multicenter cohort study
por: Pastori, Daniele, et al.
Publicado: (2021)

Added Fructose in Non-Alcoholic Fatty Liver Disease and in Metabolic Syndrome: A Narrative Review
por: Coronati, Mattia, et al.
Publicado: (2022)

Oxidative stress mediated arterial dysfunction in patients with obstructive sleep apnoea and the effect of continuous positive airway pressure treatment
por: Del Ben, Maria, et al.
Publicado: (2012)

Remnant Lipoprotein Cholesterol and Cardiovascular and Cerebrovascular Events in Patients with Non-Alcoholic Fatty Liver Disease
por: Pastori, Daniele, et al.
Publicado: (2018)

Atherogenic Dyslipidemia in Children: Evaluation of Clinical, Biochemical and Genetic Aspects
por: Montali, Anna, et al.
Publicado: (2015)

Correction: Atherogenic Dyslipidemia in Children: Evaluation of Clinical, Biochemical and Genetic Aspects
por: Montali, Anna, et al.
Publicado: (2015)

New Insights into the Pathogenesis of Non-Alcoholic Fatty Liver Disease: Gut-Derived Lipopolysaccharides and Oxidative Stress
por: Ferro, Domenico, et al.
Publicado: (2020)

Sex-Related Differences in the Association between Metabolic Syndrome and Gallstone Disease
por: Baratta, Francesco, et al.
Publicado: (2021)

Cholesterol Remnants, Triglyceride-Rich Lipoproteins and Cardiovascular Risk
por: Baratta, Francesco, et al.
Publicado: (2023)

Rare Treatments for Rare Dyslipidemias: New Perspectives in the Treatment of Homozygous Familial Hypercholesterolemia (HoFH) and Familial Chylomicronemia Syndrome (FCS)
por: D’Erasmo, Laura, et al.
Publicado: (2021)

Proprotein Convertase Subtilisin Kexin Type 9 Inhibitors Reduce Platelet Activation Modulating ox-LDL Pathways
por: Cammisotto, Vittoria, et al.
Publicado: (2021)

Reduced lysosomal acid lipase activity: A new marker of liver disease severity across the clinical continuum of non-alcoholic fatty liver disease?
por: Baratta, Francesco, et al.
Publicado: (2019)

The Interplay between Angiopoietin-Like Proteins and Adipose Tissue: Another Piece of the Relationship between Adiposopathy and Cardiometabolic Diseases?
por: Bini, Simone, et al.
Publicado: (2021)

Long‐term hepatic safety of lomitapide in homozygous familial hypercholesterolaemia
por: Larrey, Dominique, et al.
Publicado: (2022)

Challenges in Improving Adherence to Diet and Drug Treatment in Hypercholesterolemia Patients
por: Baratta, Francesco, et al.
Publicado: (2023)

Lipid-Lowering Therapy in Patients with Coronary Heart Disease and Prior Stroke: Mission Impossible?
por: Temporelli, Pier Luigi, et al.
Publicado: (2021)

Nonalcoholic Fatty Liver Disease and the Kidney: A Review
por: Umbro, Ilaria, et al.
Publicado: (2021)

Poor Adherence to Mediterranean Diet and Serum Lipopolysaccharide Are Associated with Oxidative Stress in Patients with Non-Alcoholic Fatty Liver Disease
por: Baratta, Francesco, et al.
Publicado: (2020)

Whole-Genome Resequencing of Experimental Populations Reveals Polygenic Basis of Egg-Size Variation in Drosophila melanogaster
por: Jha, Aashish R., et al.
Publicado: (2015)

NAFLD polygenic risk score and risk of hepatocellular carcinoma in an East Asian population
por: Thomas, Claire E., et al.
Publicado: (2022)

The Fibrinogen-like Domain of ANGPTL3 Facilitates Lipolysis in 3T3-L1 Cells by Activating the Intracellular Erk Pathway
por: Bini, Simone, et al.
Publicado: (2022)

Deep Resequencing of 9 Candidate Genes Identifies a Role for ARAP1 and IGF2BP2 in Modulating Insulin Secretion Adjusted for Insulin Resistance in Obese Southern Europeans
por: Bailetti, Diego, et al.
Publicado: (2022)

Oxidative stress mediated platelet activation in patients with congenital analbuminemia: Effect of albumin infusion
por: Baratta, Francesco, et al.
Publicado: (2021)

Serum Cytokeratin-18 Is Associated with NOX2-Generated Oxidative Stress in Patients with Nonalcoholic Fatty Liver
por: Del Ben, M., et al.
Publicado: (2014)

Association of NAFLD with FGF21 Polygenic Hazard Score, and Its Interaction with Protein Intake Level in Korean Adults
por: Lee, Hae Jin, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_s76pek72l8hesb6qm3sur4cu6t