Cargando…
Chaihulonggumulitang Shows Psycho-cardiology Therapeutic Effects on Acute Myocardial Infarction by Enhancing Bone Marrow Mesenchymal Stem Cells Mobilization
Ischemic myocardium initiates the mobilization and homing of bone marrow mesenchymal stem cells (BM-MSCs) to promote myocardial regeneration after acute myocardial infarction (AMI). Inflammation caused by necrotic cardiomyocytes induce major pathological changes (cardiac remodeling and myocardial ap...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829256/ https://www.ncbi.nlm.nih.gov/pubmed/29487305 http://dx.doi.org/10.1038/s41598-018-21789-w |
_version_ | 1783302767182348288 |
---|---|
author | Wang, Chao Du, Hongsen Hou, Jiqiu Yan, Shasha Yang, Jingjing Wang, Yun Zhang, Xiujing Zhu, Lili Zhao, Haibin |
author_facet | Wang, Chao Du, Hongsen Hou, Jiqiu Yan, Shasha Yang, Jingjing Wang, Yun Zhang, Xiujing Zhu, Lili Zhao, Haibin |
author_sort | Wang, Chao |
collection | PubMed |
description | Ischemic myocardium initiates the mobilization and homing of bone marrow mesenchymal stem cells (BM-MSCs) to promote myocardial regeneration after acute myocardial infarction (AMI). Inflammation caused by necrotic cardiomyocytes induce major pathological changes (cardiac remodeling and myocardial apoptosis) as well as anxiety disorder. This process may be inhibited by the differentiation and paracrine effects of BM-MSCs. However, the spontaneous mobilization of BMSCs is insufficient to prevent this effect. Given the anti-inflammatory effects of BM-MSCs, ventricular remodeling and anxiety following AMI, methods focused on enhancing BMSCs mobilization are promising. BFG is a classical traditional Chinese prescription medicine and has been proved effective in treating AMI and reducing anxiety, but the potential mechanism of its function remains unknown. In the present study, we explored the effects of Chaihulonggumulitang (BFG) on AMI and anxiety in vivo and in vitro. We also tested its effects in promoting BMSCs mobilization and alleviating inflammation. Our data showed that the classical Chinese prescription BFG promoted BM-MSCs mobilization, inhibited inflammatory response, and improved heart damage and anxiety developed from AMI. Thus, we provided an underlying mechanism of BFG function in psycho-cardiology conditions such as AMI. |
format | Online Article Text |
id | pubmed-5829256 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-58292562018-03-01 Chaihulonggumulitang Shows Psycho-cardiology Therapeutic Effects on Acute Myocardial Infarction by Enhancing Bone Marrow Mesenchymal Stem Cells Mobilization Wang, Chao Du, Hongsen Hou, Jiqiu Yan, Shasha Yang, Jingjing Wang, Yun Zhang, Xiujing Zhu, Lili Zhao, Haibin Sci Rep Article Ischemic myocardium initiates the mobilization and homing of bone marrow mesenchymal stem cells (BM-MSCs) to promote myocardial regeneration after acute myocardial infarction (AMI). Inflammation caused by necrotic cardiomyocytes induce major pathological changes (cardiac remodeling and myocardial apoptosis) as well as anxiety disorder. This process may be inhibited by the differentiation and paracrine effects of BM-MSCs. However, the spontaneous mobilization of BMSCs is insufficient to prevent this effect. Given the anti-inflammatory effects of BM-MSCs, ventricular remodeling and anxiety following AMI, methods focused on enhancing BMSCs mobilization are promising. BFG is a classical traditional Chinese prescription medicine and has been proved effective in treating AMI and reducing anxiety, but the potential mechanism of its function remains unknown. In the present study, we explored the effects of Chaihulonggumulitang (BFG) on AMI and anxiety in vivo and in vitro. We also tested its effects in promoting BMSCs mobilization and alleviating inflammation. Our data showed that the classical Chinese prescription BFG promoted BM-MSCs mobilization, inhibited inflammatory response, and improved heart damage and anxiety developed from AMI. Thus, we provided an underlying mechanism of BFG function in psycho-cardiology conditions such as AMI. Nature Publishing Group UK 2018-02-27 /pmc/articles/PMC5829256/ /pubmed/29487305 http://dx.doi.org/10.1038/s41598-018-21789-w Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Wang, Chao Du, Hongsen Hou, Jiqiu Yan, Shasha Yang, Jingjing Wang, Yun Zhang, Xiujing Zhu, Lili Zhao, Haibin Chaihulonggumulitang Shows Psycho-cardiology Therapeutic Effects on Acute Myocardial Infarction by Enhancing Bone Marrow Mesenchymal Stem Cells Mobilization |
title | Chaihulonggumulitang Shows Psycho-cardiology Therapeutic Effects on Acute Myocardial Infarction by Enhancing Bone Marrow Mesenchymal Stem Cells Mobilization |
title_full | Chaihulonggumulitang Shows Psycho-cardiology Therapeutic Effects on Acute Myocardial Infarction by Enhancing Bone Marrow Mesenchymal Stem Cells Mobilization |
title_fullStr | Chaihulonggumulitang Shows Psycho-cardiology Therapeutic Effects on Acute Myocardial Infarction by Enhancing Bone Marrow Mesenchymal Stem Cells Mobilization |
title_full_unstemmed | Chaihulonggumulitang Shows Psycho-cardiology Therapeutic Effects on Acute Myocardial Infarction by Enhancing Bone Marrow Mesenchymal Stem Cells Mobilization |
title_short | Chaihulonggumulitang Shows Psycho-cardiology Therapeutic Effects on Acute Myocardial Infarction by Enhancing Bone Marrow Mesenchymal Stem Cells Mobilization |
title_sort | chaihulonggumulitang shows psycho-cardiology therapeutic effects on acute myocardial infarction by enhancing bone marrow mesenchymal stem cells mobilization |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829256/ https://www.ncbi.nlm.nih.gov/pubmed/29487305 http://dx.doi.org/10.1038/s41598-018-21789-w |
work_keys_str_mv | AT wangchao chaihulonggumulitangshowspsychocardiologytherapeuticeffectsonacutemyocardialinfarctionbyenhancingbonemarrowmesenchymalstemcellsmobilization AT duhongsen chaihulonggumulitangshowspsychocardiologytherapeuticeffectsonacutemyocardialinfarctionbyenhancingbonemarrowmesenchymalstemcellsmobilization AT houjiqiu chaihulonggumulitangshowspsychocardiologytherapeuticeffectsonacutemyocardialinfarctionbyenhancingbonemarrowmesenchymalstemcellsmobilization AT yanshasha chaihulonggumulitangshowspsychocardiologytherapeuticeffectsonacutemyocardialinfarctionbyenhancingbonemarrowmesenchymalstemcellsmobilization AT yangjingjing chaihulonggumulitangshowspsychocardiologytherapeuticeffectsonacutemyocardialinfarctionbyenhancingbonemarrowmesenchymalstemcellsmobilization AT wangyun chaihulonggumulitangshowspsychocardiologytherapeuticeffectsonacutemyocardialinfarctionbyenhancingbonemarrowmesenchymalstemcellsmobilization AT zhangxiujing chaihulonggumulitangshowspsychocardiologytherapeuticeffectsonacutemyocardialinfarctionbyenhancingbonemarrowmesenchymalstemcellsmobilization AT zhulili chaihulonggumulitangshowspsychocardiologytherapeuticeffectsonacutemyocardialinfarctionbyenhancingbonemarrowmesenchymalstemcellsmobilization AT zhaohaibin chaihulonggumulitangshowspsychocardiologytherapeuticeffectsonacutemyocardialinfarctionbyenhancingbonemarrowmesenchymalstemcellsmobilization |