Targeted elimination of mutant mitochondrial DNA in MELAS-iPSCs by mitoTALENs

Mitochondrial diseases are maternally inherited heterogeneous disorders that are primarily caused by mitochondrial DNA (mtDNA) mutations. Depending on the ratio of mutant to wild-type mtDNA, known as heteroplasmy, mitochondrial defects can result in a wide spectrum of clinical manifestations. Mitoch...

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Detalles Bibliográficos
Autores principales: Yang, Yi, Wu, Han, Kang, Xiangjin, Liang, Yanhui, Lan, Ting, Li, Tianjie, Tan, Tao, Peng, Jiangyun, Zhang, Quanjun, An, Geng, Liu, Yali, Yu, Qian, Ma, Zhenglai, Lian, Ying, Soh, Boon Seng, Chen, Qingfeng, Liu, Ping, Chen, Yaoyong, Sun, Xiaofang, Li, Rong, Zhen, Xiumei, Yu, Yang, Li, Xiaoping, Fan, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Higher Education Press 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829275/
https://www.ncbi.nlm.nih.gov/pubmed/29318513
http://dx.doi.org/10.1007/s13238-017-0499-y

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