Labeling of DOTA-conjugated HPMA-based polymers with trivalent metallic radionuclides for molecular imaging

BACKGROUND: In this work, the in vitro and in vivo stabilities and the pharmacology of HPMA-made homopolymers were studied by means of radiometal-labeled derivatives. Aiming to identify the fewer amount and the optimal DOTA-linker structure that provides quantitative labeling yields, diverse DOTA-li...

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Detalles Bibliográficos
Autores principales: Eppard, Elisabeth, de la Fuente, Ana, Mohr, Nicole, Allmeroth, Mareli, Zentel, Rudolf, Miederer, Matthias, Pektor, Stefanie, Rösch, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829281/
https://www.ncbi.nlm.nih.gov/pubmed/29488030
http://dx.doi.org/10.1186/s13550-018-0372-x

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