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Phosphorylation of Threonine(343) Is Crucial for OCT4 Interaction with SOX2 in the Maintenance of Mouse Embryonic Stem Cell Pluripotency

OCT4 is required to maintain the pluripotency of embryonic stem cells (ESCs); yet, overdose-expression of OCT4 induces ESC differentiation toward primitive endoderm. The molecular mechanism underlying this differentiation switch is not fully understood. Here, we found that substitution of threonine(...

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Detalles Bibliográficos
Autores principales:	Abulaiti, Xianmixinuer, Zhang, Han, Wang, Aifang, Li, Na, Li, Yang, Wang, Chenchen, Du, Xiaojuan, Li, Lingsong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829306/ https://www.ncbi.nlm.nih.gov/pubmed/28988986 http://dx.doi.org/10.1016/j.stemcr.2017.09.001

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