Water-Soluble Polymer Assists N-Methyl-D-Aspartic Acid Receptor 2B siRNA Delivery to Relieve Chronic Inflammatory Pain In Vitro and In Vivo

We constructed a water-soluble lipopolymer (WSLP) as a nonviral gene carrier to deliver siRNA targeting NR2B. The cytotoxicity and serum stability of WSLP loaded with siRNA were evaluated, and the knockdown efficiency of WSLP/NR2B-siRNA in PC12 cells was examined. The results showed that WSLP could...

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Detalles Bibliográficos
Autores principales: Peng, Jie, Ma, Jiahui, Yang, Xue, He, Huan, Wu, Haopeng, Ma, Tongtong, Lu, Jianhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829431/
https://www.ncbi.nlm.nih.gov/pubmed/29623145
http://dx.doi.org/10.1155/2018/7436060

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