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Oxidative stress favours herpes virus infection in vertebrates: a meta-analysis
Herpes viruses are responsible for a variety of pathological effects in humans and in both wild and domestic animals. One mechanism that has been proposed to facilitate replication and activity of herpes viruses is oxidative stress (OS). We used meta-analytical techniques to test the hypotheses that...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829443/ https://www.ncbi.nlm.nih.gov/pubmed/29491920 http://dx.doi.org/10.1093/cz/zow019 |
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author | Sebastiano, Manrico Chastel, Olivier de Thoisy, Benoît Eens, Marcel Costantini, David |
author_facet | Sebastiano, Manrico Chastel, Olivier de Thoisy, Benoît Eens, Marcel Costantini, David |
author_sort | Sebastiano, Manrico |
collection | PubMed |
description | Herpes viruses are responsible for a variety of pathological effects in humans and in both wild and domestic animals. One mechanism that has been proposed to facilitate replication and activity of herpes viruses is oxidative stress (OS). We used meta-analytical techniques to test the hypotheses that (1) herpes virus infection causes OS and (2) supplementation of antioxidants reduces virus load, indicating that replication is favoured by a state of OS. Results based on studies on mammals, including humans, and birds show that (1) OS is indeed increased by herpes virus infection across multiple tissues and species, (2) biomarkers of OS may change differently between tissues, and (3) the effect size does not differ among different virus strains. In addition, the increase of oxidative damage in blood (tissue commonly available in ecological studies) was similar to that in the tissues most sensitive to the herpes virus. Our results also show that administration of antioxidants reduces virus yield, indicating that a condition of OS is favorable for the viral replication. In addition, some antioxidants may be more efficient than others in reducing herpes virus yield. Our results point to a potential mechanism linking herpes virus infection to individual health status. |
format | Online Article Text |
id | pubmed-5829443 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-58294432018-02-28 Oxidative stress favours herpes virus infection in vertebrates: a meta-analysis Sebastiano, Manrico Chastel, Olivier de Thoisy, Benoît Eens, Marcel Costantini, David Curr Zool Articles Herpes viruses are responsible for a variety of pathological effects in humans and in both wild and domestic animals. One mechanism that has been proposed to facilitate replication and activity of herpes viruses is oxidative stress (OS). We used meta-analytical techniques to test the hypotheses that (1) herpes virus infection causes OS and (2) supplementation of antioxidants reduces virus load, indicating that replication is favoured by a state of OS. Results based on studies on mammals, including humans, and birds show that (1) OS is indeed increased by herpes virus infection across multiple tissues and species, (2) biomarkers of OS may change differently between tissues, and (3) the effect size does not differ among different virus strains. In addition, the increase of oxidative damage in blood (tissue commonly available in ecological studies) was similar to that in the tissues most sensitive to the herpes virus. Our results also show that administration of antioxidants reduces virus yield, indicating that a condition of OS is favorable for the viral replication. In addition, some antioxidants may be more efficient than others in reducing herpes virus yield. Our results point to a potential mechanism linking herpes virus infection to individual health status. Oxford University Press 2016-08 2016-03-17 /pmc/articles/PMC5829443/ /pubmed/29491920 http://dx.doi.org/10.1093/cz/zow019 Text en © The Author (2016). Published by Oxford University Press. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Articles Sebastiano, Manrico Chastel, Olivier de Thoisy, Benoît Eens, Marcel Costantini, David Oxidative stress favours herpes virus infection in vertebrates: a meta-analysis |
title | Oxidative stress favours herpes virus infection in vertebrates: a
meta-analysis |
title_full | Oxidative stress favours herpes virus infection in vertebrates: a
meta-analysis |
title_fullStr | Oxidative stress favours herpes virus infection in vertebrates: a
meta-analysis |
title_full_unstemmed | Oxidative stress favours herpes virus infection in vertebrates: a
meta-analysis |
title_short | Oxidative stress favours herpes virus infection in vertebrates: a
meta-analysis |
title_sort | oxidative stress favours herpes virus infection in vertebrates: a
meta-analysis |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829443/ https://www.ncbi.nlm.nih.gov/pubmed/29491920 http://dx.doi.org/10.1093/cz/zow019 |
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