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Oxidative stress favours herpes virus infection in vertebrates: a meta-analysis

Herpes viruses are responsible for a variety of pathological effects in humans and in both wild and domestic animals. One mechanism that has been proposed to facilitate replication and activity of herpes viruses is oxidative stress (OS). We used meta-analytical techniques to test the hypotheses that...

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Autores principales: Sebastiano, Manrico, Chastel, Olivier, de Thoisy, Benoît, Eens, Marcel, Costantini, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829443/
https://www.ncbi.nlm.nih.gov/pubmed/29491920
http://dx.doi.org/10.1093/cz/zow019
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author Sebastiano, Manrico
Chastel, Olivier
de Thoisy, Benoît
Eens, Marcel
Costantini, David
author_facet Sebastiano, Manrico
Chastel, Olivier
de Thoisy, Benoît
Eens, Marcel
Costantini, David
author_sort Sebastiano, Manrico
collection PubMed
description Herpes viruses are responsible for a variety of pathological effects in humans and in both wild and domestic animals. One mechanism that has been proposed to facilitate replication and activity of herpes viruses is oxidative stress (OS). We used meta-analytical techniques to test the hypotheses that (1) herpes virus infection causes OS and (2) supplementation of antioxidants reduces virus load, indicating that replication is favoured by a state of OS. Results based on studies on mammals, including humans, and birds show that (1) OS is indeed increased by herpes virus infection across multiple tissues and species, (2) biomarkers of OS may change differently between tissues, and (3) the effect size does not differ among different virus strains. In addition, the increase of oxidative damage in blood (tissue commonly available in ecological studies) was similar to that in the tissues most sensitive to the herpes virus. Our results also show that administration of antioxidants reduces virus yield, indicating that a condition of OS is favorable for the viral replication. In addition, some antioxidants may be more efficient than others in reducing herpes virus yield. Our results point to a potential mechanism linking herpes virus infection to individual health status.
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spelling pubmed-58294432018-02-28 Oxidative stress favours herpes virus infection in vertebrates: a meta-analysis Sebastiano, Manrico Chastel, Olivier de Thoisy, Benoît Eens, Marcel Costantini, David Curr Zool Articles Herpes viruses are responsible for a variety of pathological effects in humans and in both wild and domestic animals. One mechanism that has been proposed to facilitate replication and activity of herpes viruses is oxidative stress (OS). We used meta-analytical techniques to test the hypotheses that (1) herpes virus infection causes OS and (2) supplementation of antioxidants reduces virus load, indicating that replication is favoured by a state of OS. Results based on studies on mammals, including humans, and birds show that (1) OS is indeed increased by herpes virus infection across multiple tissues and species, (2) biomarkers of OS may change differently between tissues, and (3) the effect size does not differ among different virus strains. In addition, the increase of oxidative damage in blood (tissue commonly available in ecological studies) was similar to that in the tissues most sensitive to the herpes virus. Our results also show that administration of antioxidants reduces virus yield, indicating that a condition of OS is favorable for the viral replication. In addition, some antioxidants may be more efficient than others in reducing herpes virus yield. Our results point to a potential mechanism linking herpes virus infection to individual health status. Oxford University Press 2016-08 2016-03-17 /pmc/articles/PMC5829443/ /pubmed/29491920 http://dx.doi.org/10.1093/cz/zow019 Text en © The Author (2016). Published by Oxford University Press. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Articles
Sebastiano, Manrico
Chastel, Olivier
de Thoisy, Benoît
Eens, Marcel
Costantini, David
Oxidative stress favours herpes virus infection in vertebrates: a meta-analysis
title Oxidative stress favours herpes virus infection in vertebrates: a meta-analysis
title_full Oxidative stress favours herpes virus infection in vertebrates: a meta-analysis
title_fullStr Oxidative stress favours herpes virus infection in vertebrates: a meta-analysis
title_full_unstemmed Oxidative stress favours herpes virus infection in vertebrates: a meta-analysis
title_short Oxidative stress favours herpes virus infection in vertebrates: a meta-analysis
title_sort oxidative stress favours herpes virus infection in vertebrates: a meta-analysis
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829443/
https://www.ncbi.nlm.nih.gov/pubmed/29491920
http://dx.doi.org/10.1093/cz/zow019
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