Cefminox, a Dual Agonist of Prostacyclin Receptor and Peroxisome Proliferator-Activated Receptor-Gamma Identified by Virtual Screening, Has Therapeutic Efficacy against Hypoxia-Induced Pulmonary Hypertension in Rats

Prostacyclin receptor (IP) and peroxisome proliferator-activated receptor-gamma (PPARγ) are both potential targets for treatment of pulmonary arterial hypertension (PAH). Expression of IP and PPARγ decreases in PAH, suggesting that screening of dual agonists of IP and PPARγ might be an efficient met...

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Detalles Bibliográficos
Autores principales: Xia, Jingwen, Yang, Li, Dong, Liang, Niu, Mengjie, Zhang, Shengli, Yang, Zhiwei, Wumaier, Gulinuer, Li, Ying, Wei, Xiaomin, Gong, Yi, Zhu, Ning, Li, Shengqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829529/
https://www.ncbi.nlm.nih.gov/pubmed/29527168
http://dx.doi.org/10.3389/fphar.2018.00134

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