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A Rare Presentation of Cryptococcal Meningitis and Cerebellitis in an Asplenic Patient, Seronegative for Human Immunodeficiency Virus (HIV)

Patient: Male, 65 Final Diagnosis: Cryptococcal meningitis Symptoms: Fever Medication: — Clinical Procedure: — Specialty: Infectious Diseases OBJECTIVE: Rare co-existance of disease or pathology BACKGROUND: Cryptococcal meningitis in patients who are seronegative for the human immunodeficiency virus...

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Autores principales: Abbas, Hafsa, Kottkamp, Angelica CiFuentes, Abbas, Naeem, Cindrich, Richard, Singh, Manisha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829552/
https://www.ncbi.nlm.nih.gov/pubmed/29456239
http://dx.doi.org/10.12659/AJCR.906869
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author Abbas, Hafsa
Kottkamp, Angelica CiFuentes
Abbas, Naeem
Cindrich, Richard
Singh, Manisha
author_facet Abbas, Hafsa
Kottkamp, Angelica CiFuentes
Abbas, Naeem
Cindrich, Richard
Singh, Manisha
author_sort Abbas, Hafsa
collection PubMed
description Patient: Male, 65 Final Diagnosis: Cryptococcal meningitis Symptoms: Fever Medication: — Clinical Procedure: — Specialty: Infectious Diseases OBJECTIVE: Rare co-existance of disease or pathology BACKGROUND: Cryptococcal meningitis in patients who are seronegative for the human immunodeficiency virus (HIV) and in patients who are splenectomized is rare. This report is an unusual case of meningeal and cerebellar infection due to the encapsulated yeast, Cryptococcus neoformans, which has not previously been associated with asplenia. CASE REPORT: A 65-year-old HIV-negative patient with a previous splenectomy, presented with a three-day history of fever, vomiting, and headache. His symptoms progressed to generalized body aches, persistent fever, and neck stiffness. A lumbar puncture was performed, and cerebrospinal fluid (CSF) culture grew Cryptococcus neoformans. Treatment commenced with intravenous amphotericin B and flucytosine. The patient required serial lumbar punctures due to persistent raised intracranial pressure (ICP). Magnetic resonance imaging (MRI) of the brain showed acute meningitis and cerebellitis. Antimicrobial therapy and CSF drainage resulted in clinical improvement. CONCLUSIONS: The occurrence of meningeal and cerebellar cryptococcosis in an asplenic patient is rare, and few cases have been previously reported. This case report highlights the possibility of invasive cryptococcal infection, or cryptococcosis, in asplenic individuals in the absence of HIV infection.
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spelling pubmed-58295522018-03-02 A Rare Presentation of Cryptococcal Meningitis and Cerebellitis in an Asplenic Patient, Seronegative for Human Immunodeficiency Virus (HIV) Abbas, Hafsa Kottkamp, Angelica CiFuentes Abbas, Naeem Cindrich, Richard Singh, Manisha Am J Case Rep Articles Patient: Male, 65 Final Diagnosis: Cryptococcal meningitis Symptoms: Fever Medication: — Clinical Procedure: — Specialty: Infectious Diseases OBJECTIVE: Rare co-existance of disease or pathology BACKGROUND: Cryptococcal meningitis in patients who are seronegative for the human immunodeficiency virus (HIV) and in patients who are splenectomized is rare. This report is an unusual case of meningeal and cerebellar infection due to the encapsulated yeast, Cryptococcus neoformans, which has not previously been associated with asplenia. CASE REPORT: A 65-year-old HIV-negative patient with a previous splenectomy, presented with a three-day history of fever, vomiting, and headache. His symptoms progressed to generalized body aches, persistent fever, and neck stiffness. A lumbar puncture was performed, and cerebrospinal fluid (CSF) culture grew Cryptococcus neoformans. Treatment commenced with intravenous amphotericin B and flucytosine. The patient required serial lumbar punctures due to persistent raised intracranial pressure (ICP). Magnetic resonance imaging (MRI) of the brain showed acute meningitis and cerebellitis. Antimicrobial therapy and CSF drainage resulted in clinical improvement. CONCLUSIONS: The occurrence of meningeal and cerebellar cryptococcosis in an asplenic patient is rare, and few cases have been previously reported. This case report highlights the possibility of invasive cryptococcal infection, or cryptococcosis, in asplenic individuals in the absence of HIV infection. International Scientific Literature, Inc. 2018-02-19 /pmc/articles/PMC5829552/ /pubmed/29456239 http://dx.doi.org/10.12659/AJCR.906869 Text en © Am J Case Rep, 2018 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Articles
Abbas, Hafsa
Kottkamp, Angelica CiFuentes
Abbas, Naeem
Cindrich, Richard
Singh, Manisha
A Rare Presentation of Cryptococcal Meningitis and Cerebellitis in an Asplenic Patient, Seronegative for Human Immunodeficiency Virus (HIV)
title A Rare Presentation of Cryptococcal Meningitis and Cerebellitis in an Asplenic Patient, Seronegative for Human Immunodeficiency Virus (HIV)
title_full A Rare Presentation of Cryptococcal Meningitis and Cerebellitis in an Asplenic Patient, Seronegative for Human Immunodeficiency Virus (HIV)
title_fullStr A Rare Presentation of Cryptococcal Meningitis and Cerebellitis in an Asplenic Patient, Seronegative for Human Immunodeficiency Virus (HIV)
title_full_unstemmed A Rare Presentation of Cryptococcal Meningitis and Cerebellitis in an Asplenic Patient, Seronegative for Human Immunodeficiency Virus (HIV)
title_short A Rare Presentation of Cryptococcal Meningitis and Cerebellitis in an Asplenic Patient, Seronegative for Human Immunodeficiency Virus (HIV)
title_sort rare presentation of cryptococcal meningitis and cerebellitis in an asplenic patient, seronegative for human immunodeficiency virus (hiv)
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829552/
https://www.ncbi.nlm.nih.gov/pubmed/29456239
http://dx.doi.org/10.12659/AJCR.906869
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