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Structural properties and gene-silencing activity of chemically modified DNA–RNA hybrids with parallel orientation

We report, herein, a new class of RNAi trigger molecules based on the unconventional parallel hybridization of two oligonucleotide chains. We have prepared and studied several parallel stranded (ps) duplexes, in which the parallel orientation is achieved through incorporation of isoguanine and isocy...

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Detalles Bibliográficos
Autores principales:	Habibian, Maryam, Yahyaee-Anzahaee, Maryam, Lucic, Matije, Moroz, Elena, Martín-Pintado, Nerea, Di Giovanni, Logan Dante, Leroux, Jean-Christophe, Hall, Jonathan, González, Carlos, Damha, Masad J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829573/ https://www.ncbi.nlm.nih.gov/pubmed/29373740 http://dx.doi.org/10.1093/nar/gky024

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