Structure–activity relationships and cellular mechanism of action of small molecules that enhance the delivery of oligonucleotides

The pharmacological effects of antisense and siRNA oligonucleotides are hindered by the tendency of these molecules to become entrapped in endomembrane compartments thus failing to reach their targets in the cytosol or nucleus. We have previously used high throughput screening to identify small mole...

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Detalles Bibliográficos
Autores principales: Juliano, Rudolph L, Wang, Ling, Tavares, Francis, Brown, Edward G, James, Lindsey, Ariyarathna, Yamuna, Ming, Xin, Mao, Chengqiong, Suto, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829638/
https://www.ncbi.nlm.nih.gov/pubmed/29361039
http://dx.doi.org/10.1093/nar/gkx1320

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829638/
https://www.ncbi.nlm.nih.gov/pubmed/29361039
http://dx.doi.org/10.1093/nar/gkx1320

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