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Structure–activity relationships and cellular mechanism of action of small molecules that enhance the delivery of oligonucleotides
The pharmacological effects of antisense and siRNA oligonucleotides are hindered by the tendency of these molecules to become entrapped in endomembrane compartments thus failing to reach their targets in the cytosol or nucleus. We have previously used high throughput screening to identify small mole...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829638/ https://www.ncbi.nlm.nih.gov/pubmed/29361039 http://dx.doi.org/10.1093/nar/gkx1320 |