Metabolic and chemical regulation of tRNA modification associated with taurine deficiency and human disease

Modified uridine containing taurine, 5-taurinomethyluridine (τm(5)U), is found at the anticodon first position of mitochondrial (mt-)transfer RNAs (tRNAs). Previously, we reported that τm(5)U is absent in mt-tRNAs with pathogenic mutations associated with mitochondrial diseases. However, biogenesis...

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Detalles Bibliográficos
Autores principales: Asano, Kana, Suzuki, Takeo, Saito, Ayaka, Wei, Fan-Yan, Ikeuchi, Yoshiho, Numata, Tomoyuki, Tanaka, Ryou, Yamane, Yoshihisa, Yamamoto, Takeshi, Goto, Takanobu, Kishita, Yoshihito, Murayama, Kei, Ohtake, Akira, Okazaki, Yasushi, Tomizawa, Kazuhito, Sakaguchi, Yuriko, Suzuki, Tsutomu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
NAR Breakthrough Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829720/
https://www.ncbi.nlm.nih.gov/pubmed/29390138
http://dx.doi.org/10.1093/nar/gky068

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