Systematic editing of synthetic RIG-I ligands to produce effective antiviral and anti-tumor RNA immunotherapies

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Retinoic acid-inducible gene I (RIG-I) recognizes double-stranded viral RNAs (dsRNAs) containing two or three 5′ phosphates. A few reports of 5′-PPP-independent RIG-I agonists have emerged, but little is known about the molecular principles underlying their recognition. We recently found that the be...

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Detalles Bibliográficos
Autores principales: Lee, Janghyun, Park, Eun-Byeol, Min, Jiyoun, Sung, Si-Eun, Jang, Yejin, Shin, Jin Soo, Chun, Dongmin, Kim, Ki-Hun, Hwang, Jihyun, Lee, Mi-Kyung, Go, Yun Young, Kwon, Dohyeong, Kim, Meehyein, Kang, Suk-Jo, Choi, Byong-Seok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829749/
https://www.ncbi.nlm.nih.gov/pubmed/29373735
http://dx.doi.org/10.1093/nar/gky039
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