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TEXT messages to improve MEDication adherence and Secondary prevention (TEXTMEDS) after acute coronary syndrome: a randomised clinical trial protocol
BACKGROUND: Identifying simple, low-cost and scalable means of supporting lifestyle change and medication adherence for patients following a cardiovascular (CV) event is important. OBJECTIVE: The TEXTMEDS (TEXT messages to improve MEDication adherence and Secondary prevention) study aims to investig...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829769/ https://www.ncbi.nlm.nih.gov/pubmed/29374674 http://dx.doi.org/10.1136/bmjopen-2017-019463 |
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author | Chow, Clara K Thiagalingam, Aravinda Santo, Karla Kok, Cindy Thakkar, Jay Stepien, Sandrine Billot, Laurent Jan, Stephen Joshi, Rohina Hillis, Graham S Brieger, David Chew, Derek P Rådholm, Karin Atherton, John J Bhindi, Ravinay Collins, Nicholas Coverdale, Steven Hamilton-Craig, Christian Kangaharan, Nadarajah Maiorana, Andrew McGrady, Michelle Shetty, Pratap Thompson, Peter Rogers, Anthony Redfern, Julie |
author_facet | Chow, Clara K Thiagalingam, Aravinda Santo, Karla Kok, Cindy Thakkar, Jay Stepien, Sandrine Billot, Laurent Jan, Stephen Joshi, Rohina Hillis, Graham S Brieger, David Chew, Derek P Rådholm, Karin Atherton, John J Bhindi, Ravinay Collins, Nicholas Coverdale, Steven Hamilton-Craig, Christian Kangaharan, Nadarajah Maiorana, Andrew McGrady, Michelle Shetty, Pratap Thompson, Peter Rogers, Anthony Redfern, Julie |
author_sort | Chow, Clara K |
collection | PubMed |
description | BACKGROUND: Identifying simple, low-cost and scalable means of supporting lifestyle change and medication adherence for patients following a cardiovascular (CV) event is important. OBJECTIVE: The TEXTMEDS (TEXT messages to improve MEDication adherence and Secondary prevention) study aims to investigate whether a cardiac education and support programme sent via mobile phone text message improves medication adherence and risk factor levels in patients following an acute coronary syndrome (ACS). STUDY DESIGN: A single-blind, multicentre, randomised clinical trial of 1400 patients after an ACS with 12 months follow-up. The intervention group will receive multiple weekly text messages that provide information, motivation, support to adhere to medications, quit smoking (if relevant) and recommendations for healthy diet and exercise. The primary endpoint is the percentage of patients who are adherent to cardioprotective medications and the key secondary outcomes are mean systolic blood pressure (BP) and low-density lipoprotein cholesterol. Secondary outcomes will also include total cholesterol, mean diastolic BP, the percentage of participants who are adherent to each cardioprotective medication class, the percentage of participants who achieve target levels of CV risk factors, major vascular events, hospital readmissions and all-cause mortality. The study will be augmented by formal economic and process evaluations to assess acceptability, utility and cost-effectiveness. SUMMARY: The study will provide multicentre randomised trial evidence of the effects of a text message-based programme on cardioprotective medication adherence and levels of CV risk factors. ETHICS AND DISSEMINATION: Primary ethics approval was received from Western Sydney Local Health District Human Research Ethics Committee (HREC2012/12/4.1 (3648) AU RED HREC/13/WMEAD/15). Results will be disseminated via peer-reviewed publications and presentations at international conferences. TRIAL REGISTRATION NUMBER: ACTRN12613000793718; Pre-results. |
format | Online Article Text |
id | pubmed-5829769 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-58297692018-03-05 TEXT messages to improve MEDication adherence and Secondary prevention (TEXTMEDS) after acute coronary syndrome: a randomised clinical trial protocol Chow, Clara K Thiagalingam, Aravinda Santo, Karla Kok, Cindy Thakkar, Jay Stepien, Sandrine Billot, Laurent Jan, Stephen Joshi, Rohina Hillis, Graham S Brieger, David Chew, Derek P Rådholm, Karin Atherton, John J Bhindi, Ravinay Collins, Nicholas Coverdale, Steven Hamilton-Craig, Christian Kangaharan, Nadarajah Maiorana, Andrew McGrady, Michelle Shetty, Pratap Thompson, Peter Rogers, Anthony Redfern, Julie BMJ Open Cardiovascular Medicine BACKGROUND: Identifying simple, low-cost and scalable means of supporting lifestyle change and medication adherence for patients following a cardiovascular (CV) event is important. OBJECTIVE: The TEXTMEDS (TEXT messages to improve MEDication adherence and Secondary prevention) study aims to investigate whether a cardiac education and support programme sent via mobile phone text message improves medication adherence and risk factor levels in patients following an acute coronary syndrome (ACS). STUDY DESIGN: A single-blind, multicentre, randomised clinical trial of 1400 patients after an ACS with 12 months follow-up. The intervention group will receive multiple weekly text messages that provide information, motivation, support to adhere to medications, quit smoking (if relevant) and recommendations for healthy diet and exercise. The primary endpoint is the percentage of patients who are adherent to cardioprotective medications and the key secondary outcomes are mean systolic blood pressure (BP) and low-density lipoprotein cholesterol. Secondary outcomes will also include total cholesterol, mean diastolic BP, the percentage of participants who are adherent to each cardioprotective medication class, the percentage of participants who achieve target levels of CV risk factors, major vascular events, hospital readmissions and all-cause mortality. The study will be augmented by formal economic and process evaluations to assess acceptability, utility and cost-effectiveness. SUMMARY: The study will provide multicentre randomised trial evidence of the effects of a text message-based programme on cardioprotective medication adherence and levels of CV risk factors. ETHICS AND DISSEMINATION: Primary ethics approval was received from Western Sydney Local Health District Human Research Ethics Committee (HREC2012/12/4.1 (3648) AU RED HREC/13/WMEAD/15). Results will be disseminated via peer-reviewed publications and presentations at international conferences. TRIAL REGISTRATION NUMBER: ACTRN12613000793718; Pre-results. BMJ Publishing Group 2018-01-27 /pmc/articles/PMC5829769/ /pubmed/29374674 http://dx.doi.org/10.1136/bmjopen-2017-019463 Text en © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
spellingShingle | Cardiovascular Medicine Chow, Clara K Thiagalingam, Aravinda Santo, Karla Kok, Cindy Thakkar, Jay Stepien, Sandrine Billot, Laurent Jan, Stephen Joshi, Rohina Hillis, Graham S Brieger, David Chew, Derek P Rådholm, Karin Atherton, John J Bhindi, Ravinay Collins, Nicholas Coverdale, Steven Hamilton-Craig, Christian Kangaharan, Nadarajah Maiorana, Andrew McGrady, Michelle Shetty, Pratap Thompson, Peter Rogers, Anthony Redfern, Julie TEXT messages to improve MEDication adherence and Secondary prevention (TEXTMEDS) after acute coronary syndrome: a randomised clinical trial protocol |
title | TEXT messages to improve MEDication adherence and Secondary prevention (TEXTMEDS) after acute coronary syndrome: a randomised clinical trial protocol |
title_full | TEXT messages to improve MEDication adherence and Secondary prevention (TEXTMEDS) after acute coronary syndrome: a randomised clinical trial protocol |
title_fullStr | TEXT messages to improve MEDication adherence and Secondary prevention (TEXTMEDS) after acute coronary syndrome: a randomised clinical trial protocol |
title_full_unstemmed | TEXT messages to improve MEDication adherence and Secondary prevention (TEXTMEDS) after acute coronary syndrome: a randomised clinical trial protocol |
title_short | TEXT messages to improve MEDication adherence and Secondary prevention (TEXTMEDS) after acute coronary syndrome: a randomised clinical trial protocol |
title_sort | text messages to improve medication adherence and secondary prevention (textmeds) after acute coronary syndrome: a randomised clinical trial protocol |
topic | Cardiovascular Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829769/ https://www.ncbi.nlm.nih.gov/pubmed/29374674 http://dx.doi.org/10.1136/bmjopen-2017-019463 |
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