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SAC1 degrades its lipid substrate PtdIns4P in the endoplasmic reticulum to maintain a steep chemical gradient with donor membranes

Gradients of PtdIns4P between organelle membranes and the endoplasmic reticulum (ER) are thought to drive counter-transport of other lipids via non-vesicular traffic. This novel pathway requires the SAC1 phosphatase to degrade PtdIns4P in a ‘cis’ configuration at the ER to maintain the gradient. How...

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Detalles Bibliográficos
Autores principales:	Zewe, James P, Wills, Rachel C, Sangappa, Sahana, Goulden, Brady D, Hammond, Gerald RV
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2018
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829913/ https://www.ncbi.nlm.nih.gov/pubmed/29461204 http://dx.doi.org/10.7554/eLife.35588

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