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Opposite regulation of inhibition by adult-born granule cells during implicit versus explicit olfactory learning

Both passive exposure and active learning through reinforcement enhance fine sensory discrimination abilities. In the olfactory system, this enhancement is thought to occur partially through the integration of adult-born inhibitory interneurons resulting in a refinement of the representation of over...

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Autores principales: Mandairon, Nathalie, Kuczewski, Nicola, Kermen, Florence, Forest, Jérémy, Midroit, Maellie, Richard, Marion, Thevenet, Marc, Sacquet, Joelle, Linster, Christiane, Didier, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829916/
https://www.ncbi.nlm.nih.gov/pubmed/29489453
http://dx.doi.org/10.7554/eLife.34976
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author Mandairon, Nathalie
Kuczewski, Nicola
Kermen, Florence
Forest, Jérémy
Midroit, Maellie
Richard, Marion
Thevenet, Marc
Sacquet, Joelle
Linster, Christiane
Didier, Anne
author_facet Mandairon, Nathalie
Kuczewski, Nicola
Kermen, Florence
Forest, Jérémy
Midroit, Maellie
Richard, Marion
Thevenet, Marc
Sacquet, Joelle
Linster, Christiane
Didier, Anne
author_sort Mandairon, Nathalie
collection PubMed
description Both passive exposure and active learning through reinforcement enhance fine sensory discrimination abilities. In the olfactory system, this enhancement is thought to occur partially through the integration of adult-born inhibitory interneurons resulting in a refinement of the representation of overlapping odorants. Here, we identify in mice a novel and unexpected dissociation between passive and active learning at the level of adult-born granule cells. Specifically, while both passive and active learning processes augment neurogenesis, adult-born cells differ in their morphology, functional coupling and thus their impact on olfactory bulb output. Morphological analysis, optogenetic stimulation of adult-born neurons and mitral cell recordings revealed that passive learning induces increased inhibitory action by adult-born neurons, probably resulting in more sparse and thus less overlapping odor representations. Conversely, after active learning inhibitory action is found to be diminished due to reduced connectivity. In this case, strengthened odor response might underlie enhanced discriminability.
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spelling pubmed-58299162018-03-05 Opposite regulation of inhibition by adult-born granule cells during implicit versus explicit olfactory learning Mandairon, Nathalie Kuczewski, Nicola Kermen, Florence Forest, Jérémy Midroit, Maellie Richard, Marion Thevenet, Marc Sacquet, Joelle Linster, Christiane Didier, Anne eLife Neuroscience Both passive exposure and active learning through reinforcement enhance fine sensory discrimination abilities. In the olfactory system, this enhancement is thought to occur partially through the integration of adult-born inhibitory interneurons resulting in a refinement of the representation of overlapping odorants. Here, we identify in mice a novel and unexpected dissociation between passive and active learning at the level of adult-born granule cells. Specifically, while both passive and active learning processes augment neurogenesis, adult-born cells differ in their morphology, functional coupling and thus their impact on olfactory bulb output. Morphological analysis, optogenetic stimulation of adult-born neurons and mitral cell recordings revealed that passive learning induces increased inhibitory action by adult-born neurons, probably resulting in more sparse and thus less overlapping odor representations. Conversely, after active learning inhibitory action is found to be diminished due to reduced connectivity. In this case, strengthened odor response might underlie enhanced discriminability. eLife Sciences Publications, Ltd 2018-02-28 /pmc/articles/PMC5829916/ /pubmed/29489453 http://dx.doi.org/10.7554/eLife.34976 Text en © 2018, Mandairon et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Mandairon, Nathalie
Kuczewski, Nicola
Kermen, Florence
Forest, Jérémy
Midroit, Maellie
Richard, Marion
Thevenet, Marc
Sacquet, Joelle
Linster, Christiane
Didier, Anne
Opposite regulation of inhibition by adult-born granule cells during implicit versus explicit olfactory learning
title Opposite regulation of inhibition by adult-born granule cells during implicit versus explicit olfactory learning
title_full Opposite regulation of inhibition by adult-born granule cells during implicit versus explicit olfactory learning
title_fullStr Opposite regulation of inhibition by adult-born granule cells during implicit versus explicit olfactory learning
title_full_unstemmed Opposite regulation of inhibition by adult-born granule cells during implicit versus explicit olfactory learning
title_short Opposite regulation of inhibition by adult-born granule cells during implicit versus explicit olfactory learning
title_sort opposite regulation of inhibition by adult-born granule cells during implicit versus explicit olfactory learning
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829916/
https://www.ncbi.nlm.nih.gov/pubmed/29489453
http://dx.doi.org/10.7554/eLife.34976
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