Cargando…

The NICE-GUT trial protocol: a randomised, placebo controlled trial of oral nitazoxanide for the empiric treatment of acute gastroenteritis among Australian Aboriginal children

INTRODUCTION: Diarrhoeal disease is the second leading cause of death in children under 5 years globally, killing 525 000 annually. Australian Aboriginal and Torres Strait Islander (hereafter Aboriginal) children suffer a high burden of disease. Randomised trials in other populations suggest nitazox...

Descripción completa

Detalles Bibliográficos
Autores principales:	Waddington, Claire S, McLeod, Charlie, Morris, Peter, Bowen, Asha, Naunton, Mark, Carapetis, Jonathan, Grimwood, Keith, Robins-Browne, Roy, Kirkwood, Carl D, Baird, Robert, Green, David, Andrews, Ross, Fearon, Deborah, Francis, Joshua, Marsh, Julie A, Snelling, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2018
Materias:	Paediatrics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829923/ https://www.ncbi.nlm.nih.gov/pubmed/29391385 http://dx.doi.org/10.1136/bmjopen-2017-019632

Ejemplares similares

The ORVAC trial protocol: a phase IV, double-blind, randomised, placebo-controlled clinical trial of a third scheduled dose of Rotarix rotavirus vaccine in Australian Indigenous infants to improve protection against gastroenteritis
por: Middleton, Bianca Fleur, et al.
Publicado: (2019)

Gelatine tannate in the management of acute gastroenteritis in children: a randomised controlled trial
por: Kołodziej, Maciej, et al.
Publicado: (2018)

Efficacy and safety of gelatine tannate for the treatment of acute gastroenteritis in children: protocol of a randomised controlled trial
por: Michałek, Dorota, et al.
Publicado: (2016)

Protocol of the study: the effectiveness of pleuran in the treatment of acute gastroenteritis in children—a randomised, placebo-controlled, double-blind trial (EPTAGE)
por: Wzorek-Łyczko, Katarzyna, et al.
Publicado: (2021)

Randomised controlled trial of Lactobacillus rhamnosus (LGG) versus placebo in children presenting to the emergency department with acute gastroenteritis: the PECARN probiotic study protocol
por: Schnadower, David, et al.
Publicado: (2017)

Demographic and clinical characteristics of hospitalised unintentional poisoning in Aboriginal and non-Aboriginal preschool children in New South Wales, Australia: a population data linkage study
por: Lee, Caroline, et al.
Publicado: (2019)

Jandu Yani U ‘For All Families’ Triple P—positive parenting program in remote Australian Aboriginal communities: a study protocol for a community intervention trial
por: Andersson, Ellaina, et al.
Publicado: (2019)

Nutritional impact on Immunological maturation during Childhood in relation to the Environment (NICE): a prospective birth cohort in northern Sweden
por: Barman, Malin, et al.
Publicado: (2018)

Understanding burn injuries in Aboriginal and Torres Strait Islander children: protocol for a prospective cohort study
por: Ivers, Rebecca Q, et al.
Publicado: (2015)

Evaluation of compliance with early postbirth follow-up and unnecessary visits to the paediatric emergency department: a prospective observational study at the Lenval Children’s Hospital in Nice
por: Tran, Antoine, et al.
Publicado: (2022)

Study protocol for the Melbourne Infant Study: BCG for Allergy and Infection Reduction (MIS BAIR), a randomised controlled trial to determine the non-specific effects of neonatal BCG vaccination in a low-mortality setting
por: Messina, Nicole L, et al.
Publicado: (2019)

Pneumococcal conjugate vaccines PREVenar13 and SynflorIX in sequence or alone in high-risk Indigenous infants (PREV-IX_COMBO): protocol of a randomised controlled trial
por: Leach, Amanda Jane, et al.
Publicado: (2015)

Comparison of diagnoses of early-onset sepsis associated with use of Sepsis Risk Calculator versus NICE CG149: a prospective, population-wide cohort study in London, UK, 2020–2021
por: Piyasena, Chinthika, et al.
Publicado: (2023)

Are food and drink retailers within NHS venues adhering to NICE Quality standard 94 guidance on childhood obesity? A cross-sectional study of two large secondary care NHS hospitals in England
por: James, Alice, et al.
Publicado: (2017)

Feasibility study of a randomised controlled trial to investigate the effectiveness of using a humanoid robot to improve the social skills of children with autism spectrum disorder (Kaspar RCT): a study protocol
por: Mengoni, Silvana E, et al.
Publicado: (2017)

Antiemetic treatment for acute gastroenteritis in children: an updated Cochrane systematic review with meta-analysis and mixed treatment comparison in a Bayesian framework
por: Carter, Ben, et al.
Publicado: (2012)

HOspitalised Pneumonia Extended (HOPE) Study to reduce the long-term effects of childhood pneumonia: protocol for a multicentre, double-blind, parallel, superiority randomised controlled trial
por: Chang, Anne B, et al.
Publicado: (2019)

The Lililwan Project: study protocol for a population-based active case ascertainment study of the prevalence of fetal alcohol spectrum disorders (FASD) in remote Australian Aboriginal communities
por: Fitzpatrick, James P, et al.
Publicado: (2012)

Activity and toxicity of intramuscular 1000 iu/m(2) polyethylene glycol‐E. coli L‐asparaginase in the UKALL 2003 and UKALL 2011 clinical trials
por: Sidhu, Jasmeet, et al.
Publicado: (2022)

Influence of serum iron test results on the diagnosis of iron deficiency in children: a retrospective observational study
por: Sezgin, Gorkem, et al.
Publicado: (2021)

Early detection of Australian Aboriginal and Torres Strait Islander infants at high risk of adverse neurodevelopmental outcomes at 12 months corrected age: LEAP-CP prospective cohort study protocol
por: Luke, Carly R, et al.
Publicado: (2022)

Effect of vitamin A supplementation in women of reproductive age on cause-specific early and late infant mortality in rural Ghana: ObaapaVitA double-blind, cluster-randomised, placebo-controlled trial
por: Edmond, Karen, et al.
Publicado: (2012)

Bigiswun Kid Project: a longitudinal study of adolescents living with high rates of prenatal alcohol exposure, fetal alcohol spectrum disorder and early life trauma in remote Australian Aboriginal communities
por: Rice, Lauren J, et al.
Publicado: (2022)

Randomised placebo-controlled multicentre effectiveness trial of adjunct betamethasone therapy in hospitalised children with community-acquired pneumonia: a trial protocol for the KIDS-STEP trial
por: Kohns Vasconcelos, Malte, et al.
Publicado: (2020)

Exploring factors impacting early childhood health among Aboriginal and Torres Strait Islander families and communities: protocol for a population-based cohort study using data linkage (the ‘Defying the Odds’ study)
por: McNamara, Bridgette, et al.
Publicado: (2018)

2643. Oral Nitazoxanide for Viral Gastroenteritis: A Single-Center Experience
por: Shweta, Fnu, et al.
Publicado: (2019)

Nordic study on human milk fortification in extremely preterm infants: a randomised controlled trial—the N-forte trial
por: Jensen, Georg Bach, et al.
Publicado: (2021)

COllaborative Neonatal Network for the first European CPAM Trial (CONNECT): a study protocol for a randomised controlled trial
por: Kersten, Casper M, et al.
Publicado: (2023)

Gut-directed hypnotherapy versus standard medical treatment for nausea in children with functional nausea or functional dyspepsia: protocol of a multicentre randomised trial
por: Browne, Pamela D, et al.
Publicado: (2019)

Publication bias in pediatric emergence delirium: a cross-sectional analysis of ClinicalTrials.gov and ClinicalTrialsRegister.eu
por: Meyburg, Jochen, et al.
Publicado: (2020)

FeBRILe3 Project: protocol for a prospective pragmatic, multisite observational study and safety evaluation assessing Fever, Blood cultures and Readiness for discharge in Infants Less than 3 months old
por: Mace, Ariel Olivia, et al.
Publicado: (2020)

The effect of smell and taste of milk during tube feeding of preterm infants (the Taste trial): a protocol for a randomised controlled trial
por: Beker, Friederike, et al.
Publicado: (2019)

A multicentre, randomised trial of stabilisation with nasal high flow during neonatal endotracheal intubation (the SHINE trial): a study protocol
por: Hodgson, Kate A, et al.
Publicado: (2020)

Caffeine prophylaxis to improve intermittent hypoxaemia in infants born late preterm: a randomised controlled dosage trial (Latte Dosage Trial)
por: Oliphant, Elizabeth Anne, et al.
Publicado: (2020)

The CLOSED trial; CLOnidine compared with midazolam for SEDation of paediatric patients in the intensive care unit: study protocol for a multicentre randomised controlled trial
por: Neubert, Antje, et al.
Publicado: (2017)

Adaptive randomised controlled non-inferiority multicentre trial (the Ketodex Trial) on intranasal dexmedetomidine plus ketamine for procedural sedation in children: study protocol
por: Poonai, Naveen, et al.
Publicado: (2020)

Melatonin for sleep disorders in children with neurodevelopmental disorders: protocol for a systematic review with meta-analysis and Trial Sequential Analysis of randomised clinical trials
por: Jørgensen, Caroline Kamp, et al.
Publicado: (2022)

Providing Oxygen during Intubation in the NICU Trial (POINT): study protocol for a randomised controlled trial in the neonatal intensive care unit in the USA
por: Herrick, Heidi M, et al.
Publicado: (2023)

Safety and tolerability of a multilineage-differentiating stress-enduring cell-based product in neonatal hypoxic-ischaemic encephalopathy with therapeutic hypothermia (SHIELD trial): a clinical trial protocol open-label, non-randomised, dose-escalation trial
por: Matsuyama, Nao, et al.
Publicado: (2022)

Treating Parents to Reduce NICU Transmission of Staphylococcus aureus (TREAT PARENTS) trial: protocol of a multisite randomised, double-blind, placebo-controlled trial
por: Milstone, Aaron M, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_6r8p6i6t1r7dbuhojpcqvbp5il