TCF7L2 Genetic Variation Augments Incretin Resistance and Influences Response to a Sulfonylurea and Metformin: The Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH)

OBJECTIVE: The rs7903146 T allele in transcription factor 7 like 2 (TCF7L2) is strongly associated with type 2 diabetes (T2D), but the mechanisms for increased risk remain unclear. We evaluated the physiologic and hormonal effects of TCF7L2 genotype before and after interventions that influence gluc...

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Detalles Bibliográficos
Autores principales: Srinivasan, Shylaja, Kaur, Varinderpal, Chamarthi, Bindu, Littleton, Katherine R., Chen, Ling, Manning, Alisa K., Merino, Jordi, Thomas, Melissa K., Hudson, Margo, Goldfine, Allison, Florez, Jose C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2018
Materias:
Pathophysiology/Complications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829963/
https://www.ncbi.nlm.nih.gov/pubmed/29326107
http://dx.doi.org/10.2337/dc17-1386

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