Mapping a functional cancer genome atlas of tumor suppressors in mouse liver using AAV-CRISPR–mediated direct in vivo screening

Cancer genomics consortia have charted the landscapes of numerous human cancers. Whereas some mutations were found in classical oncogenes and tumor suppressors, others have not yet been functionally studied in vivo. To date, a comprehensive assessment of how these genes influence oncogenesis is lack...

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Detalles Bibliográficos
Autores principales: Wang, Guangchuan, Chow, Ryan D., Ye, Lupeng, Guzman, Christopher D., Dai, Xiaoyun, Dong, Matthew B., Zhang, Feng, Sharp, Phillip A., Platt, Randall J., Chen, Sidi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829971/
https://www.ncbi.nlm.nih.gov/pubmed/29503867
http://dx.doi.org/10.1126/sciadv.aao5508

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