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Extracellular vesicles in the hematopoietic microenvironment
Self-renewal and differentiation are defining characteristics of hematopoietic stem and progenitor cells, and their balanced regulation is central to lifelong function of both blood and immune systems. In addition to cell-intrinsic programs, hematopoietic stem and progenitor cell fate decisions are...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ferrata Storti Foundation
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830368/ https://www.ncbi.nlm.nih.gov/pubmed/29439185 http://dx.doi.org/10.3324/haematol.2017.183335 |
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author | Butler, John T. Abdelhamed, Sherif Kurre, Peter |
author_facet | Butler, John T. Abdelhamed, Sherif Kurre, Peter |
author_sort | Butler, John T. |
collection | PubMed |
description | Self-renewal and differentiation are defining characteristics of hematopoietic stem and progenitor cells, and their balanced regulation is central to lifelong function of both blood and immune systems. In addition to cell-intrinsic programs, hematopoietic stem and progenitor cell fate decisions are subject to extrinsic cues from within the bone marrow microenvironment and systemically. Yet, many of the paracrine and endocrine mediators that shape hematopoietic function remain to be discovered. Extracellular vesicles serve as evolutionarily conserved, constitutive regulators of cell and tissue homeostasis, with several recent reports supporting a role for extracellular vesicles in the regulation of hematopoiesis. We review the physiological and pathophysiological effects that extracellular vesicles have on bone marrow compartmental function while highlighting progress in understanding vesicle biogenesis, cargo incorporation, differential uptake, and downstream effects of vesicle internalization. This review also touches on the role of extracellular vesicles in hematopoietic stem and progenitor cell fate regulation and recent advances in therapeutic and diagnostic applications of extracellular vesicles in hematologic disorders. |
format | Online Article Text |
id | pubmed-5830368 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Ferrata Storti Foundation |
record_format | MEDLINE/PubMed |
spelling | pubmed-58303682018-03-16 Extracellular vesicles in the hematopoietic microenvironment Butler, John T. Abdelhamed, Sherif Kurre, Peter Haematologica Review Article Self-renewal and differentiation are defining characteristics of hematopoietic stem and progenitor cells, and their balanced regulation is central to lifelong function of both blood and immune systems. In addition to cell-intrinsic programs, hematopoietic stem and progenitor cell fate decisions are subject to extrinsic cues from within the bone marrow microenvironment and systemically. Yet, many of the paracrine and endocrine mediators that shape hematopoietic function remain to be discovered. Extracellular vesicles serve as evolutionarily conserved, constitutive regulators of cell and tissue homeostasis, with several recent reports supporting a role for extracellular vesicles in the regulation of hematopoiesis. We review the physiological and pathophysiological effects that extracellular vesicles have on bone marrow compartmental function while highlighting progress in understanding vesicle biogenesis, cargo incorporation, differential uptake, and downstream effects of vesicle internalization. This review also touches on the role of extracellular vesicles in hematopoietic stem and progenitor cell fate regulation and recent advances in therapeutic and diagnostic applications of extracellular vesicles in hematologic disorders. Ferrata Storti Foundation 2018-03 /pmc/articles/PMC5830368/ /pubmed/29439185 http://dx.doi.org/10.3324/haematol.2017.183335 Text en Copyright© 2018 Ferrata Storti Foundation Material published in Haematologica is covered by copyright. All rights are reserved to the Ferrata Storti Foundation. Use of published material is allowed under the following terms and conditions: https://creativecommons.org/licenses/by-nc/4.0/legalcode. Copies of published material are allowed for personal or internal use. Sharing published material for non-commercial purposes is subject to the following conditions: https://creativecommons.org/licenses/by-nc/4.0/legalcode, sect. 3. Reproducing and sharing published material for commercial purposes is not allowed without permission in writing from the publisher. |
spellingShingle | Review Article Butler, John T. Abdelhamed, Sherif Kurre, Peter Extracellular vesicles in the hematopoietic microenvironment |
title | Extracellular vesicles in the hematopoietic microenvironment |
title_full | Extracellular vesicles in the hematopoietic microenvironment |
title_fullStr | Extracellular vesicles in the hematopoietic microenvironment |
title_full_unstemmed | Extracellular vesicles in the hematopoietic microenvironment |
title_short | Extracellular vesicles in the hematopoietic microenvironment |
title_sort | extracellular vesicles in the hematopoietic microenvironment |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830368/ https://www.ncbi.nlm.nih.gov/pubmed/29439185 http://dx.doi.org/10.3324/haematol.2017.183335 |
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