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In vitro and in vivo evidence for uncoupling of B-cell receptor internalization and signaling in chronic lymphocytic leukemia

B-cell receptor activation, occurring within lymph nodes, plays a key role in the pathogenesis of chronic lymphocytic leukemia and is linked to prognosis. As well as activation of downstream signaling, receptor ligation triggers internalization, transit to acidified endosomes and degradation of liga...

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Detalles Bibliográficos
Autores principales:	Coulter, Eve M., Pepper, Andrea, Mele, Silvia, Folarin, Najeem’deen, Townsend, William, Cuthill, Kirsty, Phillips, Elizabeth H., Patten, Piers E. M., Devereux, Stephen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ferrata Storti Foundation 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830387/ https://www.ncbi.nlm.nih.gov/pubmed/29242301 http://dx.doi.org/10.3324/haematol.2017.176164

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