Aggregating sequences that occur in many proteins constitute weak spots of bacterial proteostasis

Aggregation is a sequence-specific process, nucleated by short aggregation-prone regions (APRs) that can be exploited to induce aggregation of proteins containing the same APR. Here, we find that most APRs are unique within a proteome, but that a small minority of APRs occur in many proteins. When a...

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Detalles Bibliográficos
Autores principales: Khodaparast, Ladan, Khodaparast, Laleh, Gallardo, Rodrigo, Louros, Nikolaos N., Michiels, Emiel, Ramakrishnan, Reshmi, Ramakers, Meine, Claes, Filip, Young, Lydia, Shahrooei, Mohammad, Wilkinson, Hannah, Desager, Matyas, Mengistu Tadesse, Wubishet, Nilsson, K. Peter R., Hammarström, Per, Aertsen, Abram, Carpentier, Sebastien, Van Eldere, Johan, Rousseau, Frederic, Schymkowitz, Joost
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830399/
https://www.ncbi.nlm.nih.gov/pubmed/29491361
http://dx.doi.org/10.1038/s41467-018-03131-0

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