FcαRI co-stimulation converts human intestinal CD103(+) dendritic cells into pro-inflammatory cells through glycolytic reprogramming

CD103(+) dendritic cells (DC) are crucial for regulation of intestinal tolerance in humans. However, upon infection of the lamina propria this tolerogenic response is converted to an inflammatory response. Here we show that immunoglobulin A (IgA) immune complexes (IgA-IC), which are present after ba...

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Detalles Bibliográficos
Autores principales: Hansen, Ivo S., Krabbendam, Lisette, Bernink, Jochem H., Loayza-Puch, Fabricio, Hoepel, Willianne, van Burgsteden, Johan A., Kuijper, Elsa C., Buskens, Christianne J., Bemelman, Willem A., Zaat, Sebastiaan A. J., Agami, Reuven, Vidarsson, Gestur, van den Brink, Gijs R., de Jong, Esther C., Wildenberg, Manon E., Baeten, Dominique L. P., Everts, Bart, den Dunnen, Jeroen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830413/
https://www.ncbi.nlm.nih.gov/pubmed/29491406
http://dx.doi.org/10.1038/s41467-018-03318-5

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