Conversion of RpoS(−) Attenuated Salmonella enterica Serovar Typhi Vaccine Strains to RpoS(+) Improves Their Resistance to Host Defense Barriers

The vast majority of live attenuated typhoid vaccines are constructed from the Salmonella enterica serovar Typhi strain Ty2, which is devoid of a functioning alternative sigma factor, RpoS, due to the presence of a frameshift mutation. RpoS is a specialized sigma factor that plays an important role...

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Detalles Bibliográficos
Autores principales: Burda, Whittney N., Brenneman, Karen E., Gonzales, Amanda, Curtiss, Roy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Resource Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830471/
https://www.ncbi.nlm.nih.gov/pubmed/29507892
http://dx.doi.org/10.1128/mSphere.00006-18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830471/
https://www.ncbi.nlm.nih.gov/pubmed/29507892
http://dx.doi.org/10.1128/mSphere.00006-18

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