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Conversion of RpoS(−) Attenuated Salmonella enterica Serovar Typhi Vaccine Strains to RpoS(+) Improves Their Resistance to Host Defense Barriers
The vast majority of live attenuated typhoid vaccines are constructed from the Salmonella enterica serovar Typhi strain Ty2, which is devoid of a functioning alternative sigma factor, RpoS, due to the presence of a frameshift mutation. RpoS is a specialized sigma factor that plays an important role...
Autores principales: | Burda, Whittney N., Brenneman, Karen E., Gonzales, Amanda, Curtiss, Roy |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830471/ https://www.ncbi.nlm.nih.gov/pubmed/29507892 http://dx.doi.org/10.1128/mSphere.00006-18 |
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