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Aspirin use and ovarian cancer mortality in a Danish nationwide cohort study

BACKGROUND: Increasing data suggest that aspirin use may improve cancer survival; however, the evidence is sparse for ovarian cancer. METHODS: We examined the association between postdiagnosis use of low-dose aspirin and mortality in a nationwide cohort of women with epithelial ovarian cancer betwee...

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Autores principales: Verdoodt, Freija, Kjaer, Susanne K, Dehlendorff, Christian, Friis, Søren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830597/
https://www.ncbi.nlm.nih.gov/pubmed/29315293
http://dx.doi.org/10.1038/bjc.2017.449
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author Verdoodt, Freija
Kjaer, Susanne K
Dehlendorff, Christian
Friis, Søren
author_facet Verdoodt, Freija
Kjaer, Susanne K
Dehlendorff, Christian
Friis, Søren
author_sort Verdoodt, Freija
collection PubMed
description BACKGROUND: Increasing data suggest that aspirin use may improve cancer survival; however, the evidence is sparse for ovarian cancer. METHODS: We examined the association between postdiagnosis use of low-dose aspirin and mortality in a nationwide cohort of women with epithelial ovarian cancer between 2000 and 2012. Information on filled prescriptions of low-dose aspirin, dates and causes of death, and potential confounding factors was obtained from nationwide Danish registries. We used Cox regression models to estimate hazard ratios (HRs) with 95% confidence intervals (CIs) for ovarian cancer-specific or other-cause mortality associated with low-dose aspirin use. RESULTS: Among 4117 patients, postdiagnosis use of low-dose aspirin was associated with HRs of 1.02 (95% CI: 0.87–1.20) for ovarian cancer mortality and 1.06 (95% CI: 0.77–1.47) for other-cause mortality. Hazard ratios remained neutral according to patterns of low-dose aspirin use, including prediagnosis use or established mortality predictors. CONCLUSIONS: Low-dose aspirin use did not reduce mortality among ovarian cancer patients.
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spelling pubmed-58305972019-02-20 Aspirin use and ovarian cancer mortality in a Danish nationwide cohort study Verdoodt, Freija Kjaer, Susanne K Dehlendorff, Christian Friis, Søren Br J Cancer Epidemiology BACKGROUND: Increasing data suggest that aspirin use may improve cancer survival; however, the evidence is sparse for ovarian cancer. METHODS: We examined the association between postdiagnosis use of low-dose aspirin and mortality in a nationwide cohort of women with epithelial ovarian cancer between 2000 and 2012. Information on filled prescriptions of low-dose aspirin, dates and causes of death, and potential confounding factors was obtained from nationwide Danish registries. We used Cox regression models to estimate hazard ratios (HRs) with 95% confidence intervals (CIs) for ovarian cancer-specific or other-cause mortality associated with low-dose aspirin use. RESULTS: Among 4117 patients, postdiagnosis use of low-dose aspirin was associated with HRs of 1.02 (95% CI: 0.87–1.20) for ovarian cancer mortality and 1.06 (95% CI: 0.77–1.47) for other-cause mortality. Hazard ratios remained neutral according to patterns of low-dose aspirin use, including prediagnosis use or established mortality predictors. CONCLUSIONS: Low-dose aspirin use did not reduce mortality among ovarian cancer patients. Nature Publishing Group 2018-02-20 2018-01-09 /pmc/articles/PMC5830597/ /pubmed/29315293 http://dx.doi.org/10.1038/bjc.2017.449 Text en Copyright © 2018 Cancer Research UK http://creativecommons.org/licenses/by-nc-sa/4.0/ From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/
spellingShingle Epidemiology
Verdoodt, Freija
Kjaer, Susanne K
Dehlendorff, Christian
Friis, Søren
Aspirin use and ovarian cancer mortality in a Danish nationwide cohort study
title Aspirin use and ovarian cancer mortality in a Danish nationwide cohort study
title_full Aspirin use and ovarian cancer mortality in a Danish nationwide cohort study
title_fullStr Aspirin use and ovarian cancer mortality in a Danish nationwide cohort study
title_full_unstemmed Aspirin use and ovarian cancer mortality in a Danish nationwide cohort study
title_short Aspirin use and ovarian cancer mortality in a Danish nationwide cohort study
title_sort aspirin use and ovarian cancer mortality in a danish nationwide cohort study
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830597/
https://www.ncbi.nlm.nih.gov/pubmed/29315293
http://dx.doi.org/10.1038/bjc.2017.449
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