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Implication of liver enzymes on incident cardiovascular diseases and mortality: A nationwide population-based cohort study
Although liver enzymes, such as γ-glutamyltransferase (GGT), alanine aminotransferase (ALT), and aspartate aminotransferase (AST), have recently been suggested as risk factors for cardiovascular diseases (CVD), impact on mortality after myocardial infarction (MI) or ischemic stroke (IS) was not prev...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830612/ https://www.ncbi.nlm.nih.gov/pubmed/29491346 http://dx.doi.org/10.1038/s41598-018-19700-8 |
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author | Choi, Kyung Mook Han, Kyungdo Park, Sanghyun Chung, Hye Soo Kim, Nam Hoon Yoo, Hye Jin Seo, Ji-A Kim, Sin Gon Kim, Nan Hee Baik, Sei Hyun Park, Yong Gyu Kim, Seon Mee |
author_facet | Choi, Kyung Mook Han, Kyungdo Park, Sanghyun Chung, Hye Soo Kim, Nam Hoon Yoo, Hye Jin Seo, Ji-A Kim, Sin Gon Kim, Nan Hee Baik, Sei Hyun Park, Yong Gyu Kim, Seon Mee |
author_sort | Choi, Kyung Mook |
collection | PubMed |
description | Although liver enzymes, such as γ-glutamyltransferase (GGT), alanine aminotransferase (ALT), and aspartate aminotransferase (AST), have recently been suggested as risk factors for cardiovascular diseases (CVD), impact on mortality after myocardial infarction (MI) or ischemic stroke (IS) was not previously examined. Using a population-based, nationwide cohort database, we explored the implication of GGT and aminotransferases on the development of CVD and all-cause mortality during a median 9.1 years of follow-up. Among 16,624,006 Korean adults, both GGT and aminotransferases exhibited a positive relationship with MI, IS, and mortality in a multivariate adjusted model. ALT and AST showed U-shaped associations with mortality, whereas GGT showed a positive linear relationship with mortality. The risk of 1-year mortality after MI or IS was significantly higher in the highest quartile of GGT compared to the lowest quartile (HR, 1.46; 95% CI, 1.40-1.52). The implication of GGT on MI, IS, and mortality persisted regardless of traditional cardiovascular risk parameters. This study demonstrated the unique pattern of association of ALT, AST, and GGT with the development of CVD and all-cause mortality in the Korean population. In particular, GGT showed the most robust linear relationship with mortality before and after cardiovascular events independent of risk factors. |
format | Online Article Text |
id | pubmed-5830612 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-58306122018-03-05 Implication of liver enzymes on incident cardiovascular diseases and mortality: A nationwide population-based cohort study Choi, Kyung Mook Han, Kyungdo Park, Sanghyun Chung, Hye Soo Kim, Nam Hoon Yoo, Hye Jin Seo, Ji-A Kim, Sin Gon Kim, Nan Hee Baik, Sei Hyun Park, Yong Gyu Kim, Seon Mee Sci Rep Article Although liver enzymes, such as γ-glutamyltransferase (GGT), alanine aminotransferase (ALT), and aspartate aminotransferase (AST), have recently been suggested as risk factors for cardiovascular diseases (CVD), impact on mortality after myocardial infarction (MI) or ischemic stroke (IS) was not previously examined. Using a population-based, nationwide cohort database, we explored the implication of GGT and aminotransferases on the development of CVD and all-cause mortality during a median 9.1 years of follow-up. Among 16,624,006 Korean adults, both GGT and aminotransferases exhibited a positive relationship with MI, IS, and mortality in a multivariate adjusted model. ALT and AST showed U-shaped associations with mortality, whereas GGT showed a positive linear relationship with mortality. The risk of 1-year mortality after MI or IS was significantly higher in the highest quartile of GGT compared to the lowest quartile (HR, 1.46; 95% CI, 1.40-1.52). The implication of GGT on MI, IS, and mortality persisted regardless of traditional cardiovascular risk parameters. This study demonstrated the unique pattern of association of ALT, AST, and GGT with the development of CVD and all-cause mortality in the Korean population. In particular, GGT showed the most robust linear relationship with mortality before and after cardiovascular events independent of risk factors. Nature Publishing Group UK 2018-02-28 /pmc/articles/PMC5830612/ /pubmed/29491346 http://dx.doi.org/10.1038/s41598-018-19700-8 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Choi, Kyung Mook Han, Kyungdo Park, Sanghyun Chung, Hye Soo Kim, Nam Hoon Yoo, Hye Jin Seo, Ji-A Kim, Sin Gon Kim, Nan Hee Baik, Sei Hyun Park, Yong Gyu Kim, Seon Mee Implication of liver enzymes on incident cardiovascular diseases and mortality: A nationwide population-based cohort study |
title | Implication of liver enzymes on incident cardiovascular diseases and mortality: A nationwide population-based cohort study |
title_full | Implication of liver enzymes on incident cardiovascular diseases and mortality: A nationwide population-based cohort study |
title_fullStr | Implication of liver enzymes on incident cardiovascular diseases and mortality: A nationwide population-based cohort study |
title_full_unstemmed | Implication of liver enzymes on incident cardiovascular diseases and mortality: A nationwide population-based cohort study |
title_short | Implication of liver enzymes on incident cardiovascular diseases and mortality: A nationwide population-based cohort study |
title_sort | implication of liver enzymes on incident cardiovascular diseases and mortality: a nationwide population-based cohort study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830612/ https://www.ncbi.nlm.nih.gov/pubmed/29491346 http://dx.doi.org/10.1038/s41598-018-19700-8 |
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