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ASC- and caspase-8-dependent apoptotic pathway diverges from the NLRC4 inflammasome in macrophages

The NLRC4 inflammasome recognizes bacterial flagellin and components of the type III secretion apparatus. NLRC4 stimulation leads to caspase-1 activation followed by a rapid lytic cell death known as pyroptosis. NLRC4 is linked to pathogen-free auto-inflammatory diseases, suggesting a role for NLRC4...

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Detalles Bibliográficos
Autores principales:	Lee, Bettina L., Mirrashidi, Kathleen M., Stowe, Irma B., Kummerfeld, Sarah K., Watanabe, Colin, Haley, Benjamin, Cuellar, Trinna L., Reichelt, Michael, Kayagaki, Nobuhiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830643/ https://www.ncbi.nlm.nih.gov/pubmed/29491424 http://dx.doi.org/10.1038/s41598-018-21998-3

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