Amadori-glycated phosphatidylethanolamine enhances the physical stability and selective targeting ability of liposomes

Liposomes consisting of 100% phosphatidylcholine exhibit poor membrane fusion, cellular uptake and selective targeting capacities. To overcome these limitations, we used Amadori-glycated phosphatidylethanolamine, which is universally present in animals and commonly consumed in foods. We found that l...

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Autores principales: Miyazawa, Taiki, Kamiyoshihara, Reina, Shimizu, Naoki, Harigae, Takahiro, Otoki, Yurika, Ito, Junya, Kato, Shunji, Miyazawa, Teruo, Nakagawa, Kiyotaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society Publishing 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830733/
https://www.ncbi.nlm.nih.gov/pubmed/29515844
http://dx.doi.org/10.1098/rsos.171249
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author Miyazawa, Taiki
Kamiyoshihara, Reina
Shimizu, Naoki
Harigae, Takahiro
Otoki, Yurika
Ito, Junya
Kato, Shunji
Miyazawa, Teruo
Nakagawa, Kiyotaka
author_facet Miyazawa, Taiki
Kamiyoshihara, Reina
Shimizu, Naoki
Harigae, Takahiro
Otoki, Yurika
Ito, Junya
Kato, Shunji
Miyazawa, Teruo
Nakagawa, Kiyotaka
author_sort Miyazawa, Taiki
collection PubMed
description Liposomes consisting of 100% phosphatidylcholine exhibit poor membrane fusion, cellular uptake and selective targeting capacities. To overcome these limitations, we used Amadori-glycated phosphatidylethanolamine, which is universally present in animals and commonly consumed in foods. We found that liposomes containing Amadori-glycated phosphatidylethanolamine exhibited significantly reduced negative membrane potential and demonstrated high cellular uptake.
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spelling pubmed-58307332018-03-07 Amadori-glycated phosphatidylethanolamine enhances the physical stability and selective targeting ability of liposomes Miyazawa, Taiki Kamiyoshihara, Reina Shimizu, Naoki Harigae, Takahiro Otoki, Yurika Ito, Junya Kato, Shunji Miyazawa, Teruo Nakagawa, Kiyotaka R Soc Open Sci Chemistry Liposomes consisting of 100% phosphatidylcholine exhibit poor membrane fusion, cellular uptake and selective targeting capacities. To overcome these limitations, we used Amadori-glycated phosphatidylethanolamine, which is universally present in animals and commonly consumed in foods. We found that liposomes containing Amadori-glycated phosphatidylethanolamine exhibited significantly reduced negative membrane potential and demonstrated high cellular uptake. The Royal Society Publishing 2018-02-14 /pmc/articles/PMC5830733/ /pubmed/29515844 http://dx.doi.org/10.1098/rsos.171249 Text en © 2018 The Authors. http://creativecommons.org/licenses/by/4.0/ Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
spellingShingle Chemistry
Miyazawa, Taiki
Kamiyoshihara, Reina
Shimizu, Naoki
Harigae, Takahiro
Otoki, Yurika
Ito, Junya
Kato, Shunji
Miyazawa, Teruo
Nakagawa, Kiyotaka
Amadori-glycated phosphatidylethanolamine enhances the physical stability and selective targeting ability of liposomes
title Amadori-glycated phosphatidylethanolamine enhances the physical stability and selective targeting ability of liposomes
title_full Amadori-glycated phosphatidylethanolamine enhances the physical stability and selective targeting ability of liposomes
title_fullStr Amadori-glycated phosphatidylethanolamine enhances the physical stability and selective targeting ability of liposomes
title_full_unstemmed Amadori-glycated phosphatidylethanolamine enhances the physical stability and selective targeting ability of liposomes
title_short Amadori-glycated phosphatidylethanolamine enhances the physical stability and selective targeting ability of liposomes
title_sort amadori-glycated phosphatidylethanolamine enhances the physical stability and selective targeting ability of liposomes
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830733/
https://www.ncbi.nlm.nih.gov/pubmed/29515844
http://dx.doi.org/10.1098/rsos.171249
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