Using phosphine ligands with a biological role to modulate reactivity in novel platinum complexes

Three platinum complexes with cis and trans configuration cis-[Pt(TCEP)(2)Cl(2)], cis-[Pt(tmTCEP)(2)Cl(2)] and trans-[Pt(TCEP)(2)Cl(2)], where TCEP is tris(2-carboxyethyl)phosphine, have been synthesized and fully characterized by usual techniques including single-crystal X-ray diffraction for trans...

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Autores principales: Echeverri, Marcelo, Alvarez-Valdés, Amparo, Navas, Francisco, Perles, Josefina, Sánchez-Pérez, Isabel, Quiroga, A. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society Publishing 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830740/
https://www.ncbi.nlm.nih.gov/pubmed/29515851
http://dx.doi.org/10.1098/rsos.171340
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author Echeverri, Marcelo
Alvarez-Valdés, Amparo
Navas, Francisco
Perles, Josefina
Sánchez-Pérez, Isabel
Quiroga, A. G.
author_facet Echeverri, Marcelo
Alvarez-Valdés, Amparo
Navas, Francisco
Perles, Josefina
Sánchez-Pérez, Isabel
Quiroga, A. G.
author_sort Echeverri, Marcelo
collection PubMed
description Three platinum complexes with cis and trans configuration cis-[Pt(TCEP)(2)Cl(2)], cis-[Pt(tmTCEP)(2)Cl(2)] and trans-[Pt(TCEP)(2)Cl(2)], where TCEP is tris(2-carboxyethyl)phosphine, have been synthesized and fully characterized by usual techniques including single-crystal X-ray diffraction for trans-[Pt(TCEP)(2)Cl(2)] and cis-[Pt(tmTCEP)(2)Cl(2)]. Here, we also report on an esterification process of TCEP, which takes place in the presence of alcohols, leading to a platinum complex coordinated to an ester tmTCEP (2-methoxycarbonylethyl phosphine) ligand. The stability in solution of the three compounds and their interaction with biological models such as DNA (pBR322 and calf thymus DNA) and proteins (lysozyme and RNase) have also been studied.
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spelling pubmed-58307402018-03-07 Using phosphine ligands with a biological role to modulate reactivity in novel platinum complexes Echeverri, Marcelo Alvarez-Valdés, Amparo Navas, Francisco Perles, Josefina Sánchez-Pérez, Isabel Quiroga, A. G. R Soc Open Sci Chemistry Three platinum complexes with cis and trans configuration cis-[Pt(TCEP)(2)Cl(2)], cis-[Pt(tmTCEP)(2)Cl(2)] and trans-[Pt(TCEP)(2)Cl(2)], where TCEP is tris(2-carboxyethyl)phosphine, have been synthesized and fully characterized by usual techniques including single-crystal X-ray diffraction for trans-[Pt(TCEP)(2)Cl(2)] and cis-[Pt(tmTCEP)(2)Cl(2)]. Here, we also report on an esterification process of TCEP, which takes place in the presence of alcohols, leading to a platinum complex coordinated to an ester tmTCEP (2-methoxycarbonylethyl phosphine) ligand. The stability in solution of the three compounds and their interaction with biological models such as DNA (pBR322 and calf thymus DNA) and proteins (lysozyme and RNase) have also been studied. The Royal Society Publishing 2018-02-21 /pmc/articles/PMC5830740/ /pubmed/29515851 http://dx.doi.org/10.1098/rsos.171340 Text en © 2018 The Authors. http://creativecommons.org/licenses/by/4.0/ Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
spellingShingle Chemistry
Echeverri, Marcelo
Alvarez-Valdés, Amparo
Navas, Francisco
Perles, Josefina
Sánchez-Pérez, Isabel
Quiroga, A. G.
Using phosphine ligands with a biological role to modulate reactivity in novel platinum complexes
title Using phosphine ligands with a biological role to modulate reactivity in novel platinum complexes
title_full Using phosphine ligands with a biological role to modulate reactivity in novel platinum complexes
title_fullStr Using phosphine ligands with a biological role to modulate reactivity in novel platinum complexes
title_full_unstemmed Using phosphine ligands with a biological role to modulate reactivity in novel platinum complexes
title_short Using phosphine ligands with a biological role to modulate reactivity in novel platinum complexes
title_sort using phosphine ligands with a biological role to modulate reactivity in novel platinum complexes
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830740/
https://www.ncbi.nlm.nih.gov/pubmed/29515851
http://dx.doi.org/10.1098/rsos.171340
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