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Evidence for parallel activation of the pre-supplementary motor area and inferior frontal cortex during response inhibition: a combined MEG and TMS study

This pre-registered experiment sought to uncover the temporal relationship between the inferior frontal cortex (IFC) and the pre-supplementary motor area (pre-SMA) during stopping of an ongoing action. Both regions have previously been highlighted as being central to cognitive control of actions, pa...

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Detalles Bibliográficos
Autores principales: Allen, Christopher, Singh, Krish D., Verbruggen, Frederick, Chambers, Christopher D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society Publishing 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830741/
https://www.ncbi.nlm.nih.gov/pubmed/29515852
http://dx.doi.org/10.1098/rsos.171369
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author Allen, Christopher
Singh, Krish D.
Verbruggen, Frederick
Chambers, Christopher D.
author_facet Allen, Christopher
Singh, Krish D.
Verbruggen, Frederick
Chambers, Christopher D.
author_sort Allen, Christopher
collection PubMed
description This pre-registered experiment sought to uncover the temporal relationship between the inferior frontal cortex (IFC) and the pre-supplementary motor area (pre-SMA) during stopping of an ongoing action. Both regions have previously been highlighted as being central to cognitive control of actions, particularly response inhibition. Here we tested which area is activated first during the stopping process using magnetoencephalography, before assessing the relative chronometry of each region using functionally localized transcranial magnetic stimulation. Both lines of evidence pointed towards simultaneous activity across both regions, suggesting that parallel, mutually interdependent processing may form the cortical basis of stopping. Additional exploratory analysis, however, provided weak evidence in support of previous suggestions that the pre-SMA may provide an ongoing drive of activity to the IFC.
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spelling pubmed-58307412018-03-07 Evidence for parallel activation of the pre-supplementary motor area and inferior frontal cortex during response inhibition: a combined MEG and TMS study Allen, Christopher Singh, Krish D. Verbruggen, Frederick Chambers, Christopher D. R Soc Open Sci Psychology and Cognitive Neuroscience This pre-registered experiment sought to uncover the temporal relationship between the inferior frontal cortex (IFC) and the pre-supplementary motor area (pre-SMA) during stopping of an ongoing action. Both regions have previously been highlighted as being central to cognitive control of actions, particularly response inhibition. Here we tested which area is activated first during the stopping process using magnetoencephalography, before assessing the relative chronometry of each region using functionally localized transcranial magnetic stimulation. Both lines of evidence pointed towards simultaneous activity across both regions, suggesting that parallel, mutually interdependent processing may form the cortical basis of stopping. Additional exploratory analysis, however, provided weak evidence in support of previous suggestions that the pre-SMA may provide an ongoing drive of activity to the IFC. The Royal Society Publishing 2018-02-14 /pmc/articles/PMC5830741/ /pubmed/29515852 http://dx.doi.org/10.1098/rsos.171369 Text en © 2018 The Authors. http://creativecommons.org/licenses/by/4.0/ Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
spellingShingle Psychology and Cognitive Neuroscience
Allen, Christopher
Singh, Krish D.
Verbruggen, Frederick
Chambers, Christopher D.
Evidence for parallel activation of the pre-supplementary motor area and inferior frontal cortex during response inhibition: a combined MEG and TMS study
title Evidence for parallel activation of the pre-supplementary motor area and inferior frontal cortex during response inhibition: a combined MEG and TMS study
title_full Evidence for parallel activation of the pre-supplementary motor area and inferior frontal cortex during response inhibition: a combined MEG and TMS study
title_fullStr Evidence for parallel activation of the pre-supplementary motor area and inferior frontal cortex during response inhibition: a combined MEG and TMS study
title_full_unstemmed Evidence for parallel activation of the pre-supplementary motor area and inferior frontal cortex during response inhibition: a combined MEG and TMS study
title_short Evidence for parallel activation of the pre-supplementary motor area and inferior frontal cortex during response inhibition: a combined MEG and TMS study
title_sort evidence for parallel activation of the pre-supplementary motor area and inferior frontal cortex during response inhibition: a combined meg and tms study
topic Psychology and Cognitive Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830741/
https://www.ncbi.nlm.nih.gov/pubmed/29515852
http://dx.doi.org/10.1098/rsos.171369
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