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Direct amidation of non-activated phenylacetic acid and benzylamine derivatives catalysed by NiCl(2)

This paper describes an eco-friendly and efficient direct amidation of benzylamine and phenylacetic acid derivatives in the presence of 10 mol% NiCl(2) as catalyst without any drying agent. For the different phenylacetic acid and benzylamine derivatives, the direct catalysed amidation gave moderate-...

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Detalles Bibliográficos
Autores principales: Cheng, Lidan, Ge, Xiaoping, Huang, Longjiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society Publishing 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830780/
https://www.ncbi.nlm.nih.gov/pubmed/29515891
http://dx.doi.org/10.1098/rsos.171870
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author Cheng, Lidan
Ge, Xiaoping
Huang, Longjiang
author_facet Cheng, Lidan
Ge, Xiaoping
Huang, Longjiang
author_sort Cheng, Lidan
collection PubMed
description This paper describes an eco-friendly and efficient direct amidation of benzylamine and phenylacetic acid derivatives in the presence of 10 mol% NiCl(2) as catalyst without any drying agent. For the different phenylacetic acid and benzylamine derivatives, the direct catalysed amidation gave moderate-to-excellent yields in toluene. The steric and electronic effects of substituent groups on the phenyl ring of acid were crucial to the yields of the direct amidation. The catalyst NiCl(2) can be recycled three times without loss of activity.
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spelling pubmed-58307802018-03-07 Direct amidation of non-activated phenylacetic acid and benzylamine derivatives catalysed by NiCl(2) Cheng, Lidan Ge, Xiaoping Huang, Longjiang R Soc Open Sci Chemistry This paper describes an eco-friendly and efficient direct amidation of benzylamine and phenylacetic acid derivatives in the presence of 10 mol% NiCl(2) as catalyst without any drying agent. For the different phenylacetic acid and benzylamine derivatives, the direct catalysed amidation gave moderate-to-excellent yields in toluene. The steric and electronic effects of substituent groups on the phenyl ring of acid were crucial to the yields of the direct amidation. The catalyst NiCl(2) can be recycled three times without loss of activity. The Royal Society Publishing 2018-02-21 /pmc/articles/PMC5830780/ /pubmed/29515891 http://dx.doi.org/10.1098/rsos.171870 Text en © 2018 The Authors. http://creativecommons.org/licenses/by/4.0/ Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
spellingShingle Chemistry
Cheng, Lidan
Ge, Xiaoping
Huang, Longjiang
Direct amidation of non-activated phenylacetic acid and benzylamine derivatives catalysed by NiCl(2)
title Direct amidation of non-activated phenylacetic acid and benzylamine derivatives catalysed by NiCl(2)
title_full Direct amidation of non-activated phenylacetic acid and benzylamine derivatives catalysed by NiCl(2)
title_fullStr Direct amidation of non-activated phenylacetic acid and benzylamine derivatives catalysed by NiCl(2)
title_full_unstemmed Direct amidation of non-activated phenylacetic acid and benzylamine derivatives catalysed by NiCl(2)
title_short Direct amidation of non-activated phenylacetic acid and benzylamine derivatives catalysed by NiCl(2)
title_sort direct amidation of non-activated phenylacetic acid and benzylamine derivatives catalysed by nicl(2)
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830780/
https://www.ncbi.nlm.nih.gov/pubmed/29515891
http://dx.doi.org/10.1098/rsos.171870
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