A novel and highly efficient esterification process using triphenylphosphine oxide with oxalyl chloride

Triphenylphosphine oxide (TPPO) and oxalyl chloride ((COCl)(2)) are used as novel and high-efficiency coupling reagents for the esterification of alcohols with carboxylic acids via the TPPO/(COCl)(2) system at room temperature for 1 h. The reaction represents the first TPPO-promoted esterification u...

Descripción completa

Detalles Bibliográficos
Autores principales: Jia, Mingzhu, Jiang, Lixue, Niu, Fanfan, Zhang, Yu, Sun, Xiaoling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society Publishing 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830786/
https://www.ncbi.nlm.nih.gov/pubmed/29515897
http://dx.doi.org/10.1098/rsos.171988
Descripción
Sumario:Triphenylphosphine oxide (TPPO) and oxalyl chloride ((COCl)(2)) are used as novel and high-efficiency coupling reagents for the esterification of alcohols with carboxylic acids via the TPPO/(COCl)(2) system at room temperature for 1 h. The reaction represents the first TPPO-promoted esterification under mild and neutral conditions with excellent yields. Furthermore, we proposed a plausible mechanism with the help of (31)P NMR spectroscopy.

Ejemplares similares