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Rare Cause of Hyperkalemia in the Newborn Period: Report of Two Cases of Pseudohypoaldosteronism Type 1

Pseudohypoaldosteronism (PHA) Type 1 is characterized by mineralocorticoid resistance, manifesting as neonatal salt wasting, hypotension, hyperkalemia, hyponatremia, and metabolic acidosis in spite of elevated aldosterone levels and plasma renin activity. It is important to differentiate children wi...

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Autores principales: Manipriya, R., Umamaheswari, B., Prakash, A., Binu, N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830813/
https://www.ncbi.nlm.nih.gov/pubmed/29515305
http://dx.doi.org/10.4103/ijn.IJN_258_14
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author Manipriya, R.
Umamaheswari, B.
Prakash, A.
Binu, N.
author_facet Manipriya, R.
Umamaheswari, B.
Prakash, A.
Binu, N.
author_sort Manipriya, R.
collection PubMed
description Pseudohypoaldosteronism (PHA) Type 1 is characterized by mineralocorticoid resistance, manifesting as neonatal salt wasting, hypotension, hyperkalemia, hyponatremia, and metabolic acidosis in spite of elevated aldosterone levels and plasma renin activity. It is important to differentiate children with systemic PHA from renal PHA, as these children are likely to decompensate even with mild symptoms. Here, we report two neonates with PHA that presented to us with multiorgan involvement.
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spelling pubmed-58308132018-03-07 Rare Cause of Hyperkalemia in the Newborn Period: Report of Two Cases of Pseudohypoaldosteronism Type 1 Manipriya, R. Umamaheswari, B. Prakash, A. Binu, N. Indian J Nephrol Case Report Pseudohypoaldosteronism (PHA) Type 1 is characterized by mineralocorticoid resistance, manifesting as neonatal salt wasting, hypotension, hyperkalemia, hyponatremia, and metabolic acidosis in spite of elevated aldosterone levels and plasma renin activity. It is important to differentiate children with systemic PHA from renal PHA, as these children are likely to decompensate even with mild symptoms. Here, we report two neonates with PHA that presented to us with multiorgan involvement. Medknow Publications & Media Pvt Ltd 2018 /pmc/articles/PMC5830813/ /pubmed/29515305 http://dx.doi.org/10.4103/ijn.IJN_258_14 Text en Copyright: © 2018 Indian Journal of Nephrology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Case Report
Manipriya, R.
Umamaheswari, B.
Prakash, A.
Binu, N.
Rare Cause of Hyperkalemia in the Newborn Period: Report of Two Cases of Pseudohypoaldosteronism Type 1
title Rare Cause of Hyperkalemia in the Newborn Period: Report of Two Cases of Pseudohypoaldosteronism Type 1
title_full Rare Cause of Hyperkalemia in the Newborn Period: Report of Two Cases of Pseudohypoaldosteronism Type 1
title_fullStr Rare Cause of Hyperkalemia in the Newborn Period: Report of Two Cases of Pseudohypoaldosteronism Type 1
title_full_unstemmed Rare Cause of Hyperkalemia in the Newborn Period: Report of Two Cases of Pseudohypoaldosteronism Type 1
title_short Rare Cause of Hyperkalemia in the Newborn Period: Report of Two Cases of Pseudohypoaldosteronism Type 1
title_sort rare cause of hyperkalemia in the newborn period: report of two cases of pseudohypoaldosteronism type 1
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830813/
https://www.ncbi.nlm.nih.gov/pubmed/29515305
http://dx.doi.org/10.4103/ijn.IJN_258_14
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