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Effect of aluminum chloride on blood glucose level and lipid profile in normal, diabetic and treated diabetic rats

OBJECTIVES: The objectives of the study were to assess evaluate the effects of aluminum chloride (AlCl(3)) on blood glucose and lipid levels in normal, diabetic, and glibenclamide-treated diabetic rats. MATERIALS AND METHODS: Forty-two male Wistar rats were divided into seven groups of six each. Gro...

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Autores principales: Konda, Venugopala Rao, Eerike, Madhavi, Chary, R. Prasanth, Arunachalam, Ruckmani, Yeddula, Venkata Ramana, Meti, Vinayak, Devi, T. Sobita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830846/
https://www.ncbi.nlm.nih.gov/pubmed/29515276
http://dx.doi.org/10.4103/ijp.IJP_786_16
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author Konda, Venugopala Rao
Eerike, Madhavi
Chary, R. Prasanth
Arunachalam, Ruckmani
Yeddula, Venkata Ramana
Meti, Vinayak
Devi, T. Sobita
author_facet Konda, Venugopala Rao
Eerike, Madhavi
Chary, R. Prasanth
Arunachalam, Ruckmani
Yeddula, Venkata Ramana
Meti, Vinayak
Devi, T. Sobita
author_sort Konda, Venugopala Rao
collection PubMed
description OBJECTIVES: The objectives of the study were to assess evaluate the effects of aluminum chloride (AlCl(3)) on blood glucose and lipid levels in normal, diabetic, and glibenclamide-treated diabetic rats. MATERIALS AND METHODS: Forty-two male Wistar rats were divided into seven groups of six each. Group I was normal control, Groups II and III were given AlCl(3)50 and 100 mg/kg, and Group IV to VII were administered with streptozotocin (STZ) (60 mg/kg) intraperitoneally. Group IV was diabetic control, Group V in addition was given AlCl(3)50 mg/kg, Group VI glibenclamide (10 mg/kg), and Group VII glibenclamide and AlCl(3)(50 mg/kg) per-oral daily for 28 days. Blood glucose and lipid levels were estimated at base line, after diabetes was set in and on the last day of study. Histopathological changes in pancreas, liver, and kidney were studied. RESULTS: No significant change was observed in blood glucose and lipid levels in Group I. Group II and III showed a dose-dependent significant increase in blood glucose was observed. Group V had a reduction in blood glucose but not to the nondiabetic level. Group VI had significant reduction in blood sugar. In Group VII, treated with glibenclamide and AlCl(3), there was no significant change in blood glucose reduction compared to Group VI. Lipid levels were reduced in groups treated with AlCl(3) and glibenclamide and not in other groups. Gross tissue damage was seen in pancreas in STZ group and in liver and kidney in AlCl(3) groups. CONCLUSION: AlCl(3) administration in Wistar rats caused in significant hyperglycemia in normal rats, hypoglycemia in diabetic rats, and did not influenced hypoglycemic effect of glibenclamide and in addition, resulted in reduction in lipid levels.
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spelling pubmed-58308462018-03-07 Effect of aluminum chloride on blood glucose level and lipid profile in normal, diabetic and treated diabetic rats Konda, Venugopala Rao Eerike, Madhavi Chary, R. Prasanth Arunachalam, Ruckmani Yeddula, Venkata Ramana Meti, Vinayak Devi, T. Sobita Indian J Pharmacol Research Article OBJECTIVES: The objectives of the study were to assess evaluate the effects of aluminum chloride (AlCl(3)) on blood glucose and lipid levels in normal, diabetic, and glibenclamide-treated diabetic rats. MATERIALS AND METHODS: Forty-two male Wistar rats were divided into seven groups of six each. Group I was normal control, Groups II and III were given AlCl(3)50 and 100 mg/kg, and Group IV to VII were administered with streptozotocin (STZ) (60 mg/kg) intraperitoneally. Group IV was diabetic control, Group V in addition was given AlCl(3)50 mg/kg, Group VI glibenclamide (10 mg/kg), and Group VII glibenclamide and AlCl(3)(50 mg/kg) per-oral daily for 28 days. Blood glucose and lipid levels were estimated at base line, after diabetes was set in and on the last day of study. Histopathological changes in pancreas, liver, and kidney were studied. RESULTS: No significant change was observed in blood glucose and lipid levels in Group I. Group II and III showed a dose-dependent significant increase in blood glucose was observed. Group V had a reduction in blood glucose but not to the nondiabetic level. Group VI had significant reduction in blood sugar. In Group VII, treated with glibenclamide and AlCl(3), there was no significant change in blood glucose reduction compared to Group VI. Lipid levels were reduced in groups treated with AlCl(3) and glibenclamide and not in other groups. Gross tissue damage was seen in pancreas in STZ group and in liver and kidney in AlCl(3) groups. CONCLUSION: AlCl(3) administration in Wistar rats caused in significant hyperglycemia in normal rats, hypoglycemia in diabetic rats, and did not influenced hypoglycemic effect of glibenclamide and in addition, resulted in reduction in lipid levels. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5830846/ /pubmed/29515276 http://dx.doi.org/10.4103/ijp.IJP_786_16 Text en Copyright: © 2018 Indian Journal of Pharmacology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Research Article
Konda, Venugopala Rao
Eerike, Madhavi
Chary, R. Prasanth
Arunachalam, Ruckmani
Yeddula, Venkata Ramana
Meti, Vinayak
Devi, T. Sobita
Effect of aluminum chloride on blood glucose level and lipid profile in normal, diabetic and treated diabetic rats
title Effect of aluminum chloride on blood glucose level and lipid profile in normal, diabetic and treated diabetic rats
title_full Effect of aluminum chloride on blood glucose level and lipid profile in normal, diabetic and treated diabetic rats
title_fullStr Effect of aluminum chloride on blood glucose level and lipid profile in normal, diabetic and treated diabetic rats
title_full_unstemmed Effect of aluminum chloride on blood glucose level and lipid profile in normal, diabetic and treated diabetic rats
title_short Effect of aluminum chloride on blood glucose level and lipid profile in normal, diabetic and treated diabetic rats
title_sort effect of aluminum chloride on blood glucose level and lipid profile in normal, diabetic and treated diabetic rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830846/
https://www.ncbi.nlm.nih.gov/pubmed/29515276
http://dx.doi.org/10.4103/ijp.IJP_786_16
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