Cell-Cycle-Specific Function of p53 in Fanconi Anemia Hematopoietic Stem and Progenitor Cell Proliferation

Overactive p53 has been proposed as an important pathophysiological factor for bone marrow failure syndromes, including Fanconi anemia (FA). Here, we report a p53-dependent effect on hematopoietic stem and progenitor cell (HSPC) proliferation in mice deficient for the FA gene Fanca. Deletion of p53...

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Detalles Bibliográficos
Autores principales: Li, Xiaoli, Wilson, Andrew F., Du, Wei, Pang, Qishen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830889/
https://www.ncbi.nlm.nih.gov/pubmed/29307578
http://dx.doi.org/10.1016/j.stemcr.2017.12.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830889/
https://www.ncbi.nlm.nih.gov/pubmed/29307578
http://dx.doi.org/10.1016/j.stemcr.2017.12.006

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