Chk1 and 14‐3‐3 proteins inhibit atypical E2Fs to prevent a permanent cell cycle arrest

The atypical E2Fs, E2F7 and E2F8, act as potent transcriptional repressors of DNA replication genes providing them with the ability to induce a permanent S‐phase arrest and suppress tumorigenesis. Surprisingly in human cancer, transcript levels of atypical E2Fs are frequently elevated in proliferati...

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Detalles Bibliográficos
Autores principales: Yuan, Ruixue, Vos, Harmjan R, van Es, Robert M, Chen, Jing, Burgering, Boudewijn MT, Westendorp, Bart, de Bruin, Alain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830916/
https://www.ncbi.nlm.nih.gov/pubmed/29363506
http://dx.doi.org/10.15252/embj.201797877

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830916/
https://www.ncbi.nlm.nih.gov/pubmed/29363506
http://dx.doi.org/10.15252/embj.201797877

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