Cargando…

Chk1 and 14‐3‐3 proteins inhibit atypical E2Fs to prevent a permanent cell cycle arrest

The atypical E2Fs, E2F7 and E2F8, act as potent transcriptional repressors of DNA replication genes providing them with the ability to induce a permanent S‐phase arrest and suppress tumorigenesis. Surprisingly in human cancer, transcript levels of atypical E2Fs are frequently elevated in proliferati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yuan, Ruixue, Vos, Harmjan R, van Es, Robert M, Chen, Jing, Burgering, Boudewijn MT, Westendorp, Bart, de Bruin, Alain
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830916/ https://www.ncbi.nlm.nih.gov/pubmed/29363506 http://dx.doi.org/10.15252/embj.201797877

Ejemplares similares

Atypical E2Fs inhibit tumor angiogenesis
por: Weijts, B G M W, et al.
Publicado: (2018)

Atypical E2Fs either Counteract or Cooperate with RB during Tumorigenesis Depending on Tissue Context
por: Moreno, Eva, et al.
Publicado: (2021)

p53 Forms Redox-Dependent Protein–Protein Interactions through Cysteine 277
por: Shi, Tao, et al.
Publicado: (2021)

Atypical E2fs Control Lymphangiogenesis through Transcriptional Regulation of Ccbe1 and Flt4
por: Weijts, Bart G. M. W., et al.
Publicado: (2013)

Quantitative liver proteomics identifies FGF19 targets that couple metabolism and proliferation
por: Massafra, Vittoria, et al.
Publicado: (2017)

The Human 2-Cys Peroxiredoxins form Widespread, Cysteine-Dependent- and Isoform-Specific Protein-Protein Interactions
por: van Dam, Loes, et al.
Publicado: (2021)

Correction: Atypical E2fs Control Lymphangiogenesis through Transcriptional Regulation of Ccbe1 and Flt4
por: Weijts, Bart G. M. W., et al.
Publicado: (2013)

The Lipid Raft Component Stomatin Interacts with the Na(+) Taurocholate Cotransporting Polypeptide (NTCP) and Modulates Bile Salt Uptake
por: Appelman, Monique D., et al.
Publicado: (2020)

Metabolic rewiring in keratinocytes by miR‐31‐5p identifies therapeutic intervention for psoriasis
por: Wang, Mao‐Jie, et al.
Publicado: (2023)

Emerging insights on the role of gasdermins in infection and inflammatory diseases
por: Tang, Lipeng, et al.
Publicado: (2020)

Calnexin Depletion by Endoplasmic Reticulum Stress During Cholestasis Inhibits the Na(+)‐Taurocholate Cotransporting Polypeptide
por: Robin, Marion J.D., et al.
Publicado: (2018)

Canonical and Atypical E2Fs Regulate the Mammalian Endocycle
por: Chen, Hui-Zi, et al.
Publicado: (2012)

Dominant mutations in CHK1 cause pronuclear fusion failure and zygote arrest that can be rescued by CHK1 inhibitor
por: Zhang, Honghui, et al.
Publicado: (2021)

Chk1 C-terminal regulatory phosphorylation mediates checkpoint activation via derepression of Chk1 catalytic activity
por: Walker, M, et al.
Publicado: (2009)

Gene Expression and Interaction Analysis of FsWRKY4 and FsMAPK3 in Forsythia suspensa
por: Tan, Xinjie, et al.
Publicado: (2023)

Protocol to profile the bioenergetics of organoids using Seahorse
por: Ludikhuize, Marlies C., et al.
Publicado: (2021)

Chk1, Chk2, is the amplifier on?
por: Dove, Alan W.
Publicado: (2001)

FOXOs: masters of the equilibrium
por: Gui, Tianshu, et al.
Publicado: (2021)

Using S3 cloud storage with ROOT and CvmFS
por: Arsuaga-Ríos, Maria, et al.
Publicado: (2015)

Molecular dissection of the E6 PBM identifies essential residues regulating Chk1 phosphorylation and subsequent 14-3-3 recognition
por: Vats, Arushi, et al.
Publicado: (2023)

Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing
por: Feijoo, Carmen, et al.
Publicado: (2001)

The nucleolus stress response is coupled to an ATR-Chk1–mediated G2 arrest
por: Ma, Hanhui, et al.
Publicado: (2013)

Cyclin F‐dependent degradation of E2F7 is critical for DNA repair and G2‐phase progression
por: Yuan, Ruixue, et al.
Publicado: (2019)

Ataxin-3 promotes genome integrity by stabilizing Chk1
por: Tu, Yingfeng, et al.
Publicado: (2017)

Correction for The nucleolus stress response is coupled to an ATR-Chk1–mediated G2 arrest
Publicado: (2013)

Comprehensive Profiling of Mammalian Tribbles Interactomes Implicates TRIB3 in Gene Repression
por: Hernández-Quiles, Miguel, et al.
Publicado: (2021)

Mangrove dolabrane‐type of diterpenes tagalsins suppresses tumor growth via ROS‐mediated apoptosis and ATM/ATR–Chk1/Chk2‐regulated cell cycle arrest
por: Neumann, Jennifer, et al.
Publicado: (2015)

REVA on CephFS
por: Mouratidis, Theofilos
Publicado: (2021)

EOS on CephFS
por: van der Ster, Dan, et al.
Publicado: (2021)

EOS and SqashFS
por: Guenther, Jaroslav
Publicado: (2021)

Permanent embryo arrest: molecular and cellular concepts
por: Betts, D.H., et al.
Publicado: (2008)

A Tale of Two Clusters: CernVM-FS and CephFS in Context
por: Williamson, Jesse
Publicado: (2019)

Autonomous Synthesis of Functional, Permanently Phosphorylated Proteins for Defining the Interactome of Monomeric 14-3-3ζ
por: Zhu, Phillip, et al.
Publicado: (2023)

Regulation of Chk1
por: Tapia-Alveal, Claudia, et al.
Publicado: (2009)

HIF proteins connect the RB-E2F factors to angiogenesis
por: Bakker, Walbert. J., et al.
Publicado: (2013)

Comparative Genome Analyses of Serratia marcescens FS14 Reveals Its High Antagonistic Potential
por: Li, Pengpeng, et al.
Publicado: (2015)

Synergistic functions of E2F7 and E2F8 are critical to suppress stress-induced skin cancer
por: Thurlings, I, et al.
Publicado: (2017)

Steroidogenic control of liver metabolism through a nuclear receptor-network
por: Milona, Alexandra, et al.
Publicado: (2019)

Keeping RelApse in Chk: molecular mechanisms of Chk1 inhibitor resistance in lymphoma
por: Black, Elizabeth M., et al.
Publicado: (2022)

Permanent Sinus Node Arrest Complicating Coronary Angioplasty
por: Stratinaki, Maria, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_p83krfdm6chg6itbulr0a0n93i