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Xrn2 accelerates termination by RNA polymerase II, which is underpinned by CPSF73 activity

Termination is a ubiquitous phase in every transcription cycle but is incompletely understood and a subject of debate. We used gene editing as a new approach to address its mechanism through engineered conditional depletion of the 5′ → 3′ exonuclease Xrn2 or the polyadenylation signal (PAS) endonucl...

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Detalles Bibliográficos
Autores principales:	Eaton, Joshua D., Davidson, Lee, Bauer, David L.V., Natsume, Toyoaki, Kanemaki, Masato T., West, Steven
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830926/ https://www.ncbi.nlm.nih.gov/pubmed/29432121 http://dx.doi.org/10.1101/gad.308528.117

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