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Calcitonin receptors are ancient modulators for rhythms of preferential temperature in insects and body temperature in mammals

Daily body temperature rhythm (BTR) is essential for maintaining homeostasis. BTR is regulated separately from locomotor activity rhythms, but its molecular basis is largely unknown. While mammals internally regulate BTR, ectotherms, including Drosophila, exhibit temperature preference rhythm (TPR)...

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Autores principales: Goda, Tadahiro, Doi, Masao, Umezaki, Yujiro, Murai, Iori, Shimatani, Hiroyuki, Chu, Michelle L., Nguyen, Victoria H., Okamura, Hitoshi, Hamada, Fumika N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830927/
https://www.ncbi.nlm.nih.gov/pubmed/29440246
http://dx.doi.org/10.1101/gad.307884.117
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author Goda, Tadahiro
Doi, Masao
Umezaki, Yujiro
Murai, Iori
Shimatani, Hiroyuki
Chu, Michelle L.
Nguyen, Victoria H.
Okamura, Hitoshi
Hamada, Fumika N.
author_facet Goda, Tadahiro
Doi, Masao
Umezaki, Yujiro
Murai, Iori
Shimatani, Hiroyuki
Chu, Michelle L.
Nguyen, Victoria H.
Okamura, Hitoshi
Hamada, Fumika N.
author_sort Goda, Tadahiro
collection PubMed
description Daily body temperature rhythm (BTR) is essential for maintaining homeostasis. BTR is regulated separately from locomotor activity rhythms, but its molecular basis is largely unknown. While mammals internally regulate BTR, ectotherms, including Drosophila, exhibit temperature preference rhythm (TPR) behavior to regulate BTR. Here, we demonstrate that the diuretic hormone 31 receptor (DH31R) mediates TPR during the active phase in Drosophila. DH31R is expressed in clock cells, and its ligand, DH31, acts on clock cells to regulate TPR during the active phase. Surprisingly, the mouse homolog of DH31R, calcitonin receptor (Calcr), is expressed in the suprachiasmatic nucleus (SCN) and mediates body temperature fluctuations during the active phase in mice. Importantly, DH31R and Calcr are not required for coordinating locomotor activity rhythms. Our results represent the first molecular evidence that BTR is regulated distinctly from locomotor activity rhythms and show that DH31R/Calcr is an ancient specific mediator of BTR during the active phase in organisms ranging from ectotherms to endotherms.
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spelling pubmed-58309272018-07-15 Calcitonin receptors are ancient modulators for rhythms of preferential temperature in insects and body temperature in mammals Goda, Tadahiro Doi, Masao Umezaki, Yujiro Murai, Iori Shimatani, Hiroyuki Chu, Michelle L. Nguyen, Victoria H. Okamura, Hitoshi Hamada, Fumika N. Genes Dev Research Paper Daily body temperature rhythm (BTR) is essential for maintaining homeostasis. BTR is regulated separately from locomotor activity rhythms, but its molecular basis is largely unknown. While mammals internally regulate BTR, ectotherms, including Drosophila, exhibit temperature preference rhythm (TPR) behavior to regulate BTR. Here, we demonstrate that the diuretic hormone 31 receptor (DH31R) mediates TPR during the active phase in Drosophila. DH31R is expressed in clock cells, and its ligand, DH31, acts on clock cells to regulate TPR during the active phase. Surprisingly, the mouse homolog of DH31R, calcitonin receptor (Calcr), is expressed in the suprachiasmatic nucleus (SCN) and mediates body temperature fluctuations during the active phase in mice. Importantly, DH31R and Calcr are not required for coordinating locomotor activity rhythms. Our results represent the first molecular evidence that BTR is regulated distinctly from locomotor activity rhythms and show that DH31R/Calcr is an ancient specific mediator of BTR during the active phase in organisms ranging from ectotherms to endotherms. Cold Spring Harbor Laboratory Press 2018-01-15 /pmc/articles/PMC5830927/ /pubmed/29440246 http://dx.doi.org/10.1101/gad.307884.117 Text en © 2018 Goda et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Research Paper
Goda, Tadahiro
Doi, Masao
Umezaki, Yujiro
Murai, Iori
Shimatani, Hiroyuki
Chu, Michelle L.
Nguyen, Victoria H.
Okamura, Hitoshi
Hamada, Fumika N.
Calcitonin receptors are ancient modulators for rhythms of preferential temperature in insects and body temperature in mammals
title Calcitonin receptors are ancient modulators for rhythms of preferential temperature in insects and body temperature in mammals
title_full Calcitonin receptors are ancient modulators for rhythms of preferential temperature in insects and body temperature in mammals
title_fullStr Calcitonin receptors are ancient modulators for rhythms of preferential temperature in insects and body temperature in mammals
title_full_unstemmed Calcitonin receptors are ancient modulators for rhythms of preferential temperature in insects and body temperature in mammals
title_short Calcitonin receptors are ancient modulators for rhythms of preferential temperature in insects and body temperature in mammals
title_sort calcitonin receptors are ancient modulators for rhythms of preferential temperature in insects and body temperature in mammals
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830927/
https://www.ncbi.nlm.nih.gov/pubmed/29440246
http://dx.doi.org/10.1101/gad.307884.117
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