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IGF-1R Promotes Symmetric Self-Renewal and Migration of Alkaline Phosphatase(+) Germ Stem Cells through HIF-2α-OCT4/CXCR4 Loop under Hypoxia

Hypoxia cooperates with endocrine signaling to maintain the symmetric self-renewal proliferation and migration of embryonic germline stem cells (GSCs). However, the lack of an appropriate in vitro cell model has dramatically hindered the understanding of the mechanism underlying this cooperation. He...

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Detalles Bibliográficos
Autores principales:	Kuo, Yung-Che, Au, Heng-Kien, Hsu, Jue-Liang, Wang, Hsiao-Feng, Lee, Chiung-Ju, Peng, Syue-Wei, Lai, Ssu-Chuan, Wu, Yu-Chih, Ho, Hong-Nerng, Huang, Yen-Hua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830933/ https://www.ncbi.nlm.nih.gov/pubmed/29307582 http://dx.doi.org/10.1016/j.stemcr.2017.12.003

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