BAK/BAX-Mediated Apoptosis Is a Myc-Induced Roadblock to Reprogramming

Despite intensive efforts to optimize the process, reprogramming differentiated cells to induced pluripotent stem cells (iPSCs) remains inefficient. The most common combination of transcription factors employed comprises OCT4, KLF4, SOX2, and MYC (OKSM). If MYC is omitted (OKS), reprogramming effici...

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Detalles Bibliográficos
Autores principales: Kim, Esther J.Y., Anko, Minna-Liisa, Flensberg, Christoffer, Majewski, Ian J., Geng, Fan-Suo, Firas, Jaber, Huang, David C.S., van Delft, Mark F., Heath, Joan K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830948/
https://www.ncbi.nlm.nih.gov/pubmed/29358089
http://dx.doi.org/10.1016/j.stemcr.2017.12.019

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