Pathological Endogenous α-Synuclein Accumulation in Oligodendrocyte Precursor Cells Potentially Induces Inclusions in Multiple System Atrophy

Glial cytoplasmic inclusions (GCIs), commonly observed as α-synuclein (α-syn)-positive aggregates within oligodendrocytes, are the pathological hallmark of multiple system atrophy. The origin of α-syn in GCIs is uncertain; there is little evidence of endogenous α-syn expression in oligodendrocyte li...

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Detalles Bibliográficos
Autores principales: Kaji, Seiji, Maki, Takakuni, Kinoshita, Hisanori, Uemura, Norihito, Ayaki, Takashi, Kawamoto, Yasuhiro, Furuta, Takahiro, Urushitani, Makoto, Hasegawa, Masato, Kinoshita, Yusuke, Ono, Yuichi, Mao, Xiaobo, Quach, Tran H., Iwai, Kazuhiro, Dawson, Valina L., Dawson, Ted M., Takahashi, Ryosuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830961/
https://www.ncbi.nlm.nih.gov/pubmed/29337114
http://dx.doi.org/10.1016/j.stemcr.2017.12.001

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