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Therapeutic Effect of Cucumis melo L. Extract on Insulin Resistance and the Gut Microbiome in Lep(ob)/Lep(ob) Mice

Obesity results in the progression of metabolic disorders, especially type 2 diabetes (T2DM). Obesity-induced insulin resistance (IR) is a causative factor of T2DM morbidity in obese people. It is generally held by clinicians that IR is caused by adiposity-related inflammation that is mediated by ch...

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Autores principales: Lee, Daeun, Yoo, Jung Hwa, Lee, Byung-Cheol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830983/
https://www.ncbi.nlm.nih.gov/pubmed/29636788
http://dx.doi.org/10.1155/2018/8159261
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author Lee, Daeun
Yoo, Jung Hwa
Lee, Byung-Cheol
author_facet Lee, Daeun
Yoo, Jung Hwa
Lee, Byung-Cheol
author_sort Lee, Daeun
collection PubMed
description Obesity results in the progression of metabolic disorders, especially type 2 diabetes (T2DM). Obesity-induced insulin resistance (IR) is a causative factor of T2DM morbidity in obese people. It is generally held by clinicians that IR is caused by adiposity-related inflammation that is mediated by changes in composite ions in the gut microbiome. This experimental study was designed to investigate the effects of Cucumis melo L. (Cucumis) on obesity-induced IR in genetically leptin-deficient Lep(ob)/Lep(ob) mice. Specifically, we examined the anti-inflammatory effects of Cucumis and the effects of Cucumis on the gut microbiota. We evaluated glucose control by measuring FBS, performing the OGTT, quantifying serum IR, calculating the HOMA-IR, and determining the lipid profiles. To see whether inflammation was reduced, we analyzed adipose tissue macrophages as well as monocytes in the blood. We also profiled the gut microbiota to determine whether the ratios of microbial phyla changed. We found that Cucumis improved IR in obese mice and relieved inflammation in adipose tissue and blood. Simultaneously, the microbiota composition ratios changed. In conclusion, administration of Cucumis improved IR by reducing inflammation, thereby changing the gut microbiota composition. Cucumis is thus a promising treatment for obesity-induced insulin resistance and the inflammatory state.
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spelling pubmed-58309832018-04-10 Therapeutic Effect of Cucumis melo L. Extract on Insulin Resistance and the Gut Microbiome in Lep(ob)/Lep(ob) Mice Lee, Daeun Yoo, Jung Hwa Lee, Byung-Cheol Evid Based Complement Alternat Med Research Article Obesity results in the progression of metabolic disorders, especially type 2 diabetes (T2DM). Obesity-induced insulin resistance (IR) is a causative factor of T2DM morbidity in obese people. It is generally held by clinicians that IR is caused by adiposity-related inflammation that is mediated by changes in composite ions in the gut microbiome. This experimental study was designed to investigate the effects of Cucumis melo L. (Cucumis) on obesity-induced IR in genetically leptin-deficient Lep(ob)/Lep(ob) mice. Specifically, we examined the anti-inflammatory effects of Cucumis and the effects of Cucumis on the gut microbiota. We evaluated glucose control by measuring FBS, performing the OGTT, quantifying serum IR, calculating the HOMA-IR, and determining the lipid profiles. To see whether inflammation was reduced, we analyzed adipose tissue macrophages as well as monocytes in the blood. We also profiled the gut microbiota to determine whether the ratios of microbial phyla changed. We found that Cucumis improved IR in obese mice and relieved inflammation in adipose tissue and blood. Simultaneously, the microbiota composition ratios changed. In conclusion, administration of Cucumis improved IR by reducing inflammation, thereby changing the gut microbiota composition. Cucumis is thus a promising treatment for obesity-induced insulin resistance and the inflammatory state. Hindawi 2018-02-05 /pmc/articles/PMC5830983/ /pubmed/29636788 http://dx.doi.org/10.1155/2018/8159261 Text en Copyright © 2018 Daeun Lee et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Lee, Daeun
Yoo, Jung Hwa
Lee, Byung-Cheol
Therapeutic Effect of Cucumis melo L. Extract on Insulin Resistance and the Gut Microbiome in Lep(ob)/Lep(ob) Mice
title Therapeutic Effect of Cucumis melo L. Extract on Insulin Resistance and the Gut Microbiome in Lep(ob)/Lep(ob) Mice
title_full Therapeutic Effect of Cucumis melo L. Extract on Insulin Resistance and the Gut Microbiome in Lep(ob)/Lep(ob) Mice
title_fullStr Therapeutic Effect of Cucumis melo L. Extract on Insulin Resistance and the Gut Microbiome in Lep(ob)/Lep(ob) Mice
title_full_unstemmed Therapeutic Effect of Cucumis melo L. Extract on Insulin Resistance and the Gut Microbiome in Lep(ob)/Lep(ob) Mice
title_short Therapeutic Effect of Cucumis melo L. Extract on Insulin Resistance and the Gut Microbiome in Lep(ob)/Lep(ob) Mice
title_sort therapeutic effect of cucumis melo l. extract on insulin resistance and the gut microbiome in lep(ob)/lep(ob) mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830983/
https://www.ncbi.nlm.nih.gov/pubmed/29636788
http://dx.doi.org/10.1155/2018/8159261
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