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Schwann Cells in the Ventral Dermis Do Not Derive from Myf5-Expressing Precursors

The embryonic origin of lineage precursors of the trunk dermis is somewhat controversial. Precursor cells traced by Myf5 and Twist2 (Dermo1) promoter activation (i.e., cells of presumed dermomyotomal lineage) have been reported to generate Schwann cells. On the other hand, abundant data demonstrate...

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Detalles Bibliográficos
Autores principales: Iribar, Haizea, Pérez-López, Virginia, Etxaniz, Usue, Gutiérrez-Rivera, Araika, Izeta, Ander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830985/
https://www.ncbi.nlm.nih.gov/pubmed/29033303
http://dx.doi.org/10.1016/j.stemcr.2017.09.010
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author Iribar, Haizea
Pérez-López, Virginia
Etxaniz, Usue
Gutiérrez-Rivera, Araika
Izeta, Ander
author_facet Iribar, Haizea
Pérez-López, Virginia
Etxaniz, Usue
Gutiérrez-Rivera, Araika
Izeta, Ander
author_sort Iribar, Haizea
collection PubMed
description The embryonic origin of lineage precursors of the trunk dermis is somewhat controversial. Precursor cells traced by Myf5 and Twist2 (Dermo1) promoter activation (i.e., cells of presumed dermomyotomal lineage) have been reported to generate Schwann cells. On the other hand, abundant data demonstrate that dermal Schwann cells derive from the neural crest. This is relevant because dermal precursors give rise to neural lineages, and multilineage differentiation potential qualifies them as adult stem cells. However, it is currently unclear whether neural lineages arise from dedifferentiated Schwann cells instead of mesodermally derived dermal precursor cells. To clarify these discrepancies, we traced SOX2(+) adult dermal precursor cells by two independent Myf5 lineage tracing strains. We demonstrate that dermal Schwann cells do not belong to the Myf5(+) cell lineage, indicating that previous tracing data reflected aberrant cre recombinase expression and that bona fide Myf5(+) dermal precursors cannot transdifferentiate to neural lineages in physiological conditions.
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spelling pubmed-58309852018-03-06 Schwann Cells in the Ventral Dermis Do Not Derive from Myf5-Expressing Precursors Iribar, Haizea Pérez-López, Virginia Etxaniz, Usue Gutiérrez-Rivera, Araika Izeta, Ander Stem Cell Reports Article The embryonic origin of lineage precursors of the trunk dermis is somewhat controversial. Precursor cells traced by Myf5 and Twist2 (Dermo1) promoter activation (i.e., cells of presumed dermomyotomal lineage) have been reported to generate Schwann cells. On the other hand, abundant data demonstrate that dermal Schwann cells derive from the neural crest. This is relevant because dermal precursors give rise to neural lineages, and multilineage differentiation potential qualifies them as adult stem cells. However, it is currently unclear whether neural lineages arise from dedifferentiated Schwann cells instead of mesodermally derived dermal precursor cells. To clarify these discrepancies, we traced SOX2(+) adult dermal precursor cells by two independent Myf5 lineage tracing strains. We demonstrate that dermal Schwann cells do not belong to the Myf5(+) cell lineage, indicating that previous tracing data reflected aberrant cre recombinase expression and that bona fide Myf5(+) dermal precursors cannot transdifferentiate to neural lineages in physiological conditions. Elsevier 2017-10-12 /pmc/articles/PMC5830985/ /pubmed/29033303 http://dx.doi.org/10.1016/j.stemcr.2017.09.010 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Iribar, Haizea
Pérez-López, Virginia
Etxaniz, Usue
Gutiérrez-Rivera, Araika
Izeta, Ander
Schwann Cells in the Ventral Dermis Do Not Derive from Myf5-Expressing Precursors
title Schwann Cells in the Ventral Dermis Do Not Derive from Myf5-Expressing Precursors
title_full Schwann Cells in the Ventral Dermis Do Not Derive from Myf5-Expressing Precursors
title_fullStr Schwann Cells in the Ventral Dermis Do Not Derive from Myf5-Expressing Precursors
title_full_unstemmed Schwann Cells in the Ventral Dermis Do Not Derive from Myf5-Expressing Precursors
title_short Schwann Cells in the Ventral Dermis Do Not Derive from Myf5-Expressing Precursors
title_sort schwann cells in the ventral dermis do not derive from myf5-expressing precursors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830985/
https://www.ncbi.nlm.nih.gov/pubmed/29033303
http://dx.doi.org/10.1016/j.stemcr.2017.09.010
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