Genes Associated with Pancreas Development and Function Maintain Open Chromatin in iPSCs Generated from Human Pancreatic Beta Cells

Current in vitro islet differentiation protocols suffer from heterogeneity and low efficiency. Induced pluripotent stem cells (iPSCs) derived from pancreatic beta cells (BiPSCs) preferentially differentiate toward endocrine pancreas-like cells versus those from fibroblasts (FiPSCs). We interrogated...

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Detalles Bibliográficos
Autores principales: Thurner, Matthias, Shenhav, Liraz, Wesolowska-Andersen, Agata, Bennett, Amanda J., Barrett, Amy, Gloyn, Anna L., McCarthy, Mark I., Beer, Nicola L., Efrat, Shimon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831005/
https://www.ncbi.nlm.nih.gov/pubmed/29107594
http://dx.doi.org/10.1016/j.stemcr.2017.09.020

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