Reduced Self-Diploidization and Improved Survival of Semi-cloned Mice Produced from Androgenetic Haploid Embryonic Stem Cells through Overexpression of Dnmt3b

Androgenetic haploid embryonic stem cells (AG-haESCs) hold great promise for exploring gene functions and generating gene-edited semi-cloned (SC) mice. However, the high incidence of self-diploidization and low efficiency of SC mouse production are major obstacles preventing widespread use of these...

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Detalles Bibliográficos
Autores principales: He, Wenteng, Zhang, Xiaobai, Zhang, Yalin, Zheng, Weisheng, Xiong, Zeyu, Hu, Xinjie, Wang, Mingzhu, Zhang, Linfeng, Zhao, Kun, Qiao, Zhibin, Lai, Weiyi, Lv, Cong, Kou, Xiaochen, Zhao, Yanhong, Yin, Jiqing, Liu, Wenqiang, Jiang, Yonghua, Chen, Mo, Xu, Ruimin, Le, Rongrong, Li, Chong, Wang, Hong, Wan, Xiaoping, Wang, Hailin, Han, Zhiming, Jiang, Cizhong, Gao, Shaorong, Chen, Jiayu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831042/
https://www.ncbi.nlm.nih.gov/pubmed/29396184
http://dx.doi.org/10.1016/j.stemcr.2017.12.024

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