Naked Mole Rat Cells Have a Stable Epigenome that Resists iPSC Reprogramming

Naked mole rat (NMR) is a valuable model for aging and cancer research due to its exceptional longevity and cancer resistance. We observed that the reprogramming efficiency of NMR fibroblasts in response to OSKM was drastically lower than that of mouse fibroblasts. Expression of SV40 LargeT antigen...

Descripción completa

Detalles Bibliográficos
Autores principales: Tan, Li, Ke, Zhonghe, Tombline, Gregory, Macoretta, Nicholas, Hayes, Kevin, Tian, Xiao, Lv, Ruitu, Ablaeva, Julia, Gilbert, Michael, Bhanu, Natarajan V., Yuan, Zuo-Fei, Garcia, Benjamin A., Shi, Yujiang G., Shi, Yang, Seluanov, Andrei, Gorbunova, Vera
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831052/
https://www.ncbi.nlm.nih.gov/pubmed/29107597
http://dx.doi.org/10.1016/j.stemcr.2017.10.001

Ejemplares similares

Ejemplares similares